Category: 14161-11-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of of 3 ,4,5-trichloropyridazine (0.276 g, 1.506 mmol), 4-(3 -fluorophenyl)piperidine (0.27 g, 1.506 mmol), and potassium carbonate (0.437 g, 3.16 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.73 ml, 30.1 mmol) was added. The mixture was heated to reflux for an additional 16 h.The reaction was diluted with ethyl acetate and water. The ethyl acetate layer waswashed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(3 -fluorophenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine (0.25 g, 52%). LCMS:Rt = 1.940 mm, 26%, (M-H) = 320, (M+H) = 322., 14161-11-6

As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 3,4,5-trichloropyridazine (0.250 g, 1.363 mmol), 4-(3- methoxyphenyl)piperidine (0.26 1 g, 1.363 mmol), and potassium carbonate (0.3 96 g, 2.86 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.469 ml, 27.3 mmol) was added. The mixture was heated to reflux for 16 h. The mixture was heated to reflux for an additional 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-3-hydrazinyl- 5-(4-(2-methoxyphenyl)piperidin-1-yl)pyridazine as a brown oil oil that was usedwithout purification. LCMS: Rt = 0.77 mm, 22%, (M+H) = 334.

14161-11-6, 14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 41 3,5-Dichloro-4-(1-methylethylamino)pyridazine A solution of 3,4,5-trichloropyridazine (9.2 g) and isopropylamine (16.5 g) in toluene (25 ml) is refluxed for 18 hr. Excess isopropylamine is removed by atmospheric distillation. The residual solution is cooled and diluted with dichloromethane and aqueous sodium hydroxide solution (5%). The phases are separated. The organic phase is washed with water and then with saline. The organic phase is dried over sodium sulfate and concentrated under reduced pressure to give a liquid which contains a mixture of isomeric products. The isomers are separated by flash chromatography on silica gel eluding with ether/hexane (30/70). The appropriate fractions are pooled and concentrated to give the desired isomer, NMR (CDCl3) 1.33, 4.59, 4.87 and 8.60delta; CMR (CDCl3) 24.2, 46.4, 117.1,139.3, 145.5 and 151.3 delta. Further elution gives 3,4-dichloro-5-(1-methylethylamino)pyridine which is recrystallized from ether hexane, NMR (CDCl3) 1.35, 3.87, 4.80, and 8.55 delta; CMR (CDCl3) 22.6, 44.7, 116.5, 136.3, 142.5 and 153.4 delta., 14161-11-6

14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; The Upjohn Company; US5599930; (1997); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 4-(2-(difluoromethoxy)-3,6- difluorophenyl)piperidine (0.57 g, 2.165 mmol), 20% aqueous potassium carbonate (2.72 ml, 4.33 mmol) and 3,4,5-trichloropyridazine (0.397 g, 2.165 mmol) in dioxane (10 ml) was stirred at 90C for 2h. Hydrazine hydrate (0.799 g, 15.96 mmol) was added and the reaction mixture was stirred at 90 C for 16 h. The mixture was concentrated and the residue was diluted with ethyl acetate and saturated aqueous sodium bicarbonate. The aqueous layer was extracted with ethyl acetate (4x 10 ml). The combined organic layers were washed with additional saturated aqueous sodium bicarbonate, and was used for next step. An aliquot was purified by Prep. HPLC on a Phenomenex-Luna 30 x 100mm S10 Axia column, using 20-80% methanol/water containing 0.1% TFA to give 4-chloro-5-(4-(2-(difluoromethoxy)-3,5- difluorophenyl)piperidin-l-yl)-3-hydrazinylpyridazine for characterization. XH NMR (400MHz, METHANOL-d4) delta 8.39 (s, 1H), 7.23 – 7.14 (m, 1H), 7.12 – 7.05 (m, 1H), 6.86 (t, j=74.0 Hz, 1H), 3.89 – 3.79 (m, 2H), 3.44 – 3.34 (m, 1H), 3.05 (t, j=12.4 Hz, 2H), 2.42 – 2.24 (m, 2H), 1.87 – 1.73 (m, 2H). LCMS: M+l = 405.9.

14161-11-6, The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,4,5-trichloropyridazine (0.50 g, 2.73 mmol), 4-(2,4- difluorophenyl)piperidine (0.538 g, 2.73 mmol), and potassium carbonate (0.791 g, 5.72 mmol) in dioxane (9 ml) and water (1 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (4.94 ml, 54.5 mmol) was added. The mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water and concentrated to give 4- chloro-5-(4-(2,4-difluorophenyl)piperidin-l-yl)-3-hydrazinylpyridazine as a brown oil. LCMS: Rt = 0.74 min, (M+H)+ = 340.0. The material was used without purification., 14161-11-6

14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

EXAMPLE 95 1-[2-(Pyridazin-4-ylamino)-ethyl]-piperazin-2-one. 1-(2-Aminoethyl)-4-(tert-butyloxycarbonyl)-piperazin-2-one from EXAMPLE 92, Part A (1.0 g, 4.1 mmol) is treated with 3,4,5-trichloropyridazine (0.81 g, 4.1 mmol), triethylamine (0.57 ML, 4.1 mmol), THF (25 ML) and heated to 120 C. in a sealed tube for 3 hours.Upon cooling, the solution is diluted with ethyl acetate and washed with aqueous sodium bicarbonate (25 ML), water and dried over sodium sulfate.The organic layer is concentrated and chromatographed (5% methanol/methylene chloride) to give a mixture of isomers (0.8 g, 20 mmol).The mixture is dissolved in 0.5 M sodium methoxide in methanol (200 ML), treated with 10% Pd/C (0.5 g) and agitated under 50 PSI of hydrogen for 20 hours.The reaction mixture is filtered; the filtrate is concentrated to a residue which is chromatographed (NH4OH/H2O/MeOH/EtOAc, 1:1:2:90) to give crude 4-(tert-butyloxycarbonyl)-1-[2-(pyridazin-4-ylamino)-ethyl]-piperazin-2-one.This material is dissolved in a minimal amount of THF and treated with a saturated solution of HCl in ethyl acetate (50 ML).The solution is stirred at ambient temperature for 2 h and diluted with diethyl ether (50 ML).The precipitated title compoundcompound is collected and air dried (0.5 g, 1.7 mmol). MS m/z: 367, [M+1]+; 1H NMR (CD3OD, 300 MHz) delta8.8 (d, 1H), 8.5 (s, 1H), 7.4 (d, 1H), 4.1 (s, 2H), 3.5-3.8 (m, 8H)., 14161-11-6

14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; US2004/102450; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem