Category: 141-30-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

Hydroiodic acid (250mL) was added to a mixture of 3, 6-dichloropyridazine (149g, 1 mol CAS:[135034-10- 5]) and Nal (180g, 1 .2mol) in 500mL of CHCI3. After the addition, the mixture was stirred at ambient temperature for 24h, and poured into water and extracted with dichloromethane three times. The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo to give 3- chloro-6-iodopyridazine. H-NMR (400Mz, DMSO-d6) delta: 7.63 (d, 1 H), 8.16 (d, 1 H).

141-30-0, As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA CROP PROTECTION AG; SYNGENTA (CHINA) INVESTMENT CO., LTD.; EDMUNDS, Andrew; HALL, Roger Graham; MUEHLEBACH, Michel; EMERY, Daniel; JUNG, Pierre Joseph Marcel; LU, Long; WU, Yaming; CHEN, Ruifang; (156 pag.)WO2016/169886; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate D (1 eq.), silver nitrate (1 eq.), and the appropriate carboxylic acid (1 eq.) were dissolved in water. The reaction mixture was heated to 50C and concentrated sulfuric acid (3eq.) was added. The reaction mixture was heated to 60C and aqueous ammonium per sulphate (3eq.) was added. The reaction mixture was kept at 70C for 30 minutes before cooling to room temperature. pH was adjusted to 8 with 1 N NaOH. The mixture was extracted with ethyl acetate, dried over MgS04, filtered and evaporated. The residue was purified by chromatography on silica gel to provide the desired mono or di substituted 3,6- dichloro-[1 ,2,4]triazolo[4,3-b]pyridazine.Reaction of intermediate D with propionic acid gave a mixture of compounds. Purification on silica gel yielded 6% of 3,6-dichloro-7,8-diethyl-[1 ,2,4]triazolo[4,3-b]pyridazine and 5% of 3,6-dichloro-8-ethyl-[1 ,2,4]triazolo[4,3-b]pyridazine. These intermediates were used to prepare Cpd.5-12 and Cpd.5-13 respectively.Intermediate of Cpd.5-8 was obtained in the same manner with 15% yield.This protocol was also used to prepare intermediate of Cpd.5-14, Cpd.5-1 1 from 3,6- dichloropyridazine with appropriate carboxylic acid with 42% and 81 % yields respectively.

141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENFIT; BOUROTTE, Maryline; DELHOMEL, Jean-Francois; DUBERNET, Mathieu; GOUY, Marie-Helene; WO2013/45519; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5L, 3-neck flask was charged with 500.Og (3.356 moles) of 2,6-dichloropyridazine, followed by 1000 mL of methanol. The resulting pale yellow solution was treated with 2300 mL of a 25% (by weight) solution OfNaOCH3 in methanol over 3 hr. The resulting mixture was heated at gentle reflux for 20 hr. Afterward, the mixture was cooled to 4O0C and poured into 6000 mL water/2000 mL CH2Cl2. The aqueous layer was extracted with CH2Cl2 (2×1 L). The combined organics were then dried over MgSO4 to give a white crystalline solid. The solid was further dried in vacuo to give the title compound (458.3g ;97.5% yield). NMR spectrum (DMSO) delta ppm 3.94 (s, 6H) 7.17 (s,2H).

141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ALHAMBRA, Cristobal; CHANG, Hui-Fang (Amy); CHAPDELAINE, Marc; HERZOG, Keith, John; SCHMIESING, Richard, J; WO2011/21979; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate To a solution of 3,6-dichloropyridazine (Sigma-Aldrich, St. Louis, Mo.) (57.3 g, 385 mmol) in 1,4-dioxane (250 mL) were added tert-butyl piperazine-1-carboxylate (Sigma-Aldrich) (71.6 g, 358 mmol) and N,N-diisopropylethylamine (66.9 mL, 385 mmol). The mixture was stirred overnight at 80 C. then concentrated under reduced pressure. The residue was dissolved in ethyl acetate (3 L) and washed with 10% citric acid, water, and brine. The organic layer was concentrated and the residue was re-crystallized in ethyl acetate to provide tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate as an off-white solid (101 g, 88% yield). 1H NMR (400 MHz, CDCl3) delta ppm 1.25 (9H, s), 3.26-3.47 (8H, m), 6.67 (1H, d, J=9.6 Hz), 7.00 (1H, d, J=9.6 Hz); MS (ESI) m/z: 299.0 [M+H]+.

141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; DU, Zhimei; MCCARTER, John Douglas; REDDY, Pranhitha; SNOWDEN, Andrew William; MCGEE, Lawrence R.; ALLEN, John Gordon; TREIBER, David Lawrence; KEEGAN, Kathleen; LI, Zhihong; US2015/353542; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

2.70 kg (18.0 mol) of sodium iodide are added in portions at room temperature to a mixture of 5.0 l of water and 11.3 l of 57% aqueous hydroiodic acid (75.2 mol). 2.00 kg (13.4 mol) of 3,6-dichloropyridazine are subsequently added in portions to the solution held at 20 C. The reaction mixture is stirred at 20 C. for 18 hours. 10 l of tert-butyl methyl ether and 4 l of water are added to the reaction mixture. The organic phase is separated off and washed with water and aqueous sodium sulfite solution. The organic phase is concentrated, heptane is added, and the resultant solid is filtered off with suction and washed with heptane. The residue is dried in vacuo: 3-chloro-6-iodopyridazine as colourless leaf-shaped crystals; ESI 241., 141-30-0

The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/257181; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

XVII.1.a3,6-Diiodo-pyridazine; 14.9 g (0.1 mol) 3,6-Dichloro-pyridazine and 120 ml (0.54 mol) hydroiodic acid are refluxed for 0.5 hours at 150C. After that time the mixture is cooled down and poured into 0.4 N NaOH solution/ice water. The precipitate is filtered off, taken up in methylene chloride and dried over sodium sulphate. After evaporation of the solvent, the product is dried in vacuo at50CYield: 28.3 g (85% of theory),C4H2I2N2 EII Mass spectrum: m/z = 333 [M+H]+M. p. 165-168 C, 141-30-0

As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Hydrazine hydrate (0.25 mol, 2.5 equiv) was added dropwise to a solution of 4,6 dichloro pyrimidine 3,6 dichloro pyridazine (0.1 mol, 1 equiv) in ethanol (100 mL) for 30 C at room temperature. After stirring at 30 C for 1 h, the reaction mixture after 1 h produced a creamy precipitate. After filtering the product (78% yield), it was used for the next step in the synthesis.

141-30-0, As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Article; Rajput, Jamatsing D.; Bagul, Suresh D.; Bendre, Ratnamala S.; Research on Chemical Intermediates; vol. 43; 11; (2017); p. 6601 – 6616;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

Intermediate L6-((6-Chloro-[1 ,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Acetic acid, 500C 3-Chloro-6-hydrazinylpyridazine (i) A mixture of 3,6-dichloropyridazine (3 g, 20.14 mmol) and hydrazine monohydride(1 g, 20.14 mmol) was heated in a sealed tube to 80 0C for 5 hours. Solvent was evaporated and the crude was used in the next step without purification (3.56 g, 100%). LCMS (method B): [MH]+ = 145.1 , tR = 0.57 min.

141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FU, Xingnian; HE, Feng; LI, Yue; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YU, Zhengtian; ZHANG, Ji Yue (Jeff); DAI, Miao; WO2011/18454; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,141-30-0

Example 2. 6-4-f4- (5-Chloro-lH-indole-2-sulphonyl)-piperazine-l-carbonvl]-phenyl}-2- (2-dimethylamino-ethvl)-2H-pyridazin-3-one Step A. To a microwave vial was added 3,6-dichloropyridazine (645mg, 4.33mmol), potassium acetate (425 mg, 4.33 mmol) and 9 mL acetic acid/water (5: 1). The reaction mixture was heated at 140 C for 70 minutes. The solvent was evaporated and the crude was purified by preparative HPLC using a gradient of acetonitrile/5 % acetonitrile- water phase containing 0.1 M ammonium acetate, to give 436 mg of 6-chloro-2H- pyridazin-3-one (77 % yield). 1H NMR (400 MHz ; methanol-d4 as solvent and internal reference) delta (ppm) 6.96 (d, 1H), 7.45 (d, 1H).

As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2005/65688; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem