Awesome Chemistry Experiments For 141-30-0

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DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2 CH2 CH2; L1is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and-NH2; are useful for controlling synaptic transmission in mammal.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1247 – PubChem

 

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Related Products of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent£¬once mentioned of 141-30-0

Sulfonyl pyridazinone compounds as therapeutic agents for ischemic tissue damage

This invention relates to therapeutic methods for treatment or prevention of tissue damage resulting from ischemia in mammals.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1460 – PubChem

 

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TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-alkoxy moiety at the 6-position, are selective ligands for GABA Areceptors, in particular having high affinity for the alpha2 and/or alpha3 subunit thereof, are useful in the treatment of anxiety and convulsions.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1557 – PubChem

 

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NOVEL TRIAZOLE COMPOUNDS I

The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A ¡À5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1345 – PubChem

 

Awesome Chemistry Experiments For 3,6-Dichloropyridazine

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1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer

A compound of Formula (I): or a pharmaceutically acceptable salt thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R1 can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, or 3,3-difluoroazetidin-1-yl; R2 can be hydrogen or fluoro; R3 can be hydrogen or methoxy; and R4 can be methoxy, ethoxy, or methoxymethyl; provided that when R1 is hydrogen, methoxy or trifluoromethoxy, then R3 is not hydrogen, and/or R4 is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1465 – PubChem

 

Discovery of 141-30-0

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PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR SUBSTITUTED FIVE-MEMBERED RING HETEROCYLES

Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1302 – PubChem

 

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141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Application In Synthesis of 3,6-DichloropyridazineIn an article, once mentioned the new application about 141-30-0.

Chemical studies on 3,6-dichloropyridazine (part 2)

3,6-Dichloropyridazine (1) reacted with 2-aminophenol, phenylalanine, acetophenone hydrazone derivatives, acid hydrazide derivatives and amino-aromatic acids (anthranilic acid and 5-bromoanthranilic acid) and yield the compounds (2), (3), (4a,b), (5a,b) and (6a,b) respectively. Reaction of compounds (5a,b) with acid hydrazide gave (8a,b). Also, compounds (6a,b) reacted with aromatic amino acid and gave (7a-c). Copyright E-Journal of Chemistry 2004-2011.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1683 – PubChem

 

Discovery of 3,6-Dichloropyridazine

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Palladium-catalyzed coupling of aldehyde-derived hydrazones: Practical synthesis of triazolopyridines and related heterocycles

The palladium-catalyzed intermolecular coupling of aldehyde-derived hydrazones with chloroazines, followed by oxidative cyclization under mild conditions afforded access to a broad variety of bicyclic heterocyclic scaffolds (see scheme) that have potential for use in drug discovery.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1924 – PubChem

 

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DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZ1NES AS REV-ERB AGONISTS

The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1237 – PubChem

 

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TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS

The invention relates to novel compounds of formula I where X, A?, Q1, Q2 Q3, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1343 – PubChem