Discovery of 3,6-Dichloropyridazine

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Substituted cyclohexane derivatives

The present invention relates to compounds of formula (I) 1wherein A1, A2, A3, A4, A5, A6, U, V, m, n and o are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the 2,3-oxidosqualene-lanosterol cyclase biosynthetic pathway such as hypercholesterolemia and hyperlipemia.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1363 – PubChem

 

The important role of 3,6-Dichloropyridazine

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NOVEL 2-HETEROARYLOXY-PHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS

Antimicrobial compounds, compositions and methods of treatment administering same, of 2-heteroaryloxyphenol, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1.

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Pyridazine | C4H4N1356 – PubChem

 

Awesome Chemistry Experiments For 141-30-0

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ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

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Pyridazine | C4H4N1574 – PubChem

 

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Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1

The development and synthesis of potent p38alpha MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38alpha selective pyridopyridazin-6-one series from the p38alpha/beta dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.

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More research is needed about 141-30-0

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Synthesis of N,N-Dioxopyridazines

Despite many efforts, one of the smallest heterocycles containing two nitrogen atoms, pyridazine, could not be converted to its N,N-dioxide (see, however, Nakadate et al. Chem. Pharm. Bull. 1970, 18, 1211-1218). HOF¡¤CH3CN, made easily from diluted fluorine, was able to accomplish this task in a fast reaction with good yields.

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Synthetic Route of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein the variables A, L1, L2, R2, R11, and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

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Synthesis of some 3,6-disubstituted pyridazines

Some novel 3-halo-6-(4-substituted-phenoxy)pyridazines and 3,6-di-(4- substituted-phenoxy)pyridazines were synthesized from 3,6-dichloropyridazine or 3,6-diiodopyridazine. 3,6-Diiodopyridazine was prepared from 3,6- dichloropyridazine using hydriodic acid/iodine monochloride.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1896 – PubChem

 

Simple exploration of 141-30-0

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First principle investigations of organobismuth palladium-catalyzed C?C coupling reaction: mechanism, chemoselectivity and solvent effects

A first principle study of the cross-coupling reaction between 3-chloro-6-iodopyridazine and triphenylbismuth under palladium catalysis has been carried out. The approach selected for this investigation is the density functional theory within the framework of the PBE0 and B3LYP hybrid exchange?correlation functionals, with and without including empirical corrections for the dispersion forces at the GD3 level. For this reaction, a three-step mechanism including an oxidative addition, a transmetalation and a reductive elimination has been proposed. All intermediates and transition states have been fully characterized. The energy profile is deduced in gas phase and in solvent. Calculations suggest that the oxidative addition is the rate-determining step for the entire cross-coupling reaction.

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Properties and Exciting Facts About 3,6-Dichloropyridazine

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Immobilization of Fe(III) complexes of pyridazine derivatives prepared from biosorbents supported on zeolites

Immobilization of Fe(III) complexes of pyridazine derivatives was achieved in NaY zeolite, loaded with iron through the action of a robust biosorption mediator consisting of a bacterial biofilm, Arthrobacter viscosus, supported on the zeolite. The objective of this study is the preparation and characterization of new catalytic materials to be used in oxidation reactions under mild conditions. The biosorption of Fe(III) ions was performed starting from aqueous solutions with low concentrations of iron and the highest values of biosorption efficiency for Fe(III) were reached at the beginning of the contact period with the sorbents. The Fe(III) biosorption process was compared with the one of Cr(III) under the same experimental conditions, as this latter case has been well characterized. The sample used in the immobilization of Fe(III) complexes of pyridazine derivatives was prepared from an aqueous solution of 100.0 mgFe/L, without the competing effect of other metals. Fe(III) is retained in the zeolite by ion exchange and coordination with two different pyridazine derivative ligands, 3-ethoxy-6-chloropyridazine (A) and 3-piperidino-6-chloropyridazine (B). The resulting materials were fully characterized by different spectroscopic methods (EPR, FTIR and UV-vis), chemical analysis (CA), surface analysis (XRD and SEM) and thermogravimetric (TGA) analysis and the results indicated that the Fe(III) complexes of pyridazine derivatives were effectively immobilized in NaY inside the supercages, without any modifications of the morphology and structure of the zeolite. The EPR spectra of the Fe(III) complexes in Y zeolite show signals at g = 4.3 and 2.3, attributed to Fe(III) species coordinated to pyridazine derivative ligands.

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Discovery of 141-30-0

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TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Tetrahydroquinoline compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

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