Category: 141-30-0

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3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I?): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1198 – PubChem

 

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NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS

The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) alpha (NR1H3) and/or beta (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimers disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1420 – PubChem

 

Reference of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF

According to the present invention, a compound represented by the following formula (I) having a superior PPARalpha, agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for the compound can be provided.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1545 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 3,6-Dichloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

Synthesis of azulenic compounds substituted in the 1-position with heterocycles

Abstract: The review proposes an overview of the important general routes for the achievement of 1-heteroarylazulenes using both azulene substitution by heterocycles and azulenic cyclic construction pathways. With strong electrophilic heterocyclic derivatives, the electrophilic substitution takes place while concerted route is adopted for medium and low reactive heterocyclic substrates. Particular attention has been paid to the heterocycles construction from the functional groups attached to azulenic 1-position.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 3,6-Dichloropyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1874 – PubChem

 

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Anti-allergy activity of 10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acids

A series of substituted 10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acids was prepared and evaluated as anti-allergy agents. The 8-chloro and unsubstituted analogues were more potent than cromolyn sodium and doxantrazole intravenously in the rat PCA test. None of the analogues possessed significant oral activity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1890 – PubChem

 

Application of 141-30-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article£¬once mentioned of 141-30-0

INHIBITORS OF PI3 KINASE

The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1514 – PubChem

 

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Fungicidal pyridazines

Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is hydrogen, methyl, ethyl or n-propyl; R2 is STR2 X is fluoro, chloro, bromo or iodo; X1 and X2 independently represent X or hydrogen, provided that no more than one of X1 and X2 is hydrogen; R4 is hydrogen, chloro, bromo, methyl or ethyl; R5 is hydrogen, chloro, methyl, ethyl, chloromethyl or dichloromethyl; or R4 and R5 combine with the group to which they are attached to form a C3 -C7 cycloalkyl group substituted with a R1 group; R6 is hydrogen, chloro, bromo, methyl or ethyl; R7 is hydrogen, methyl, ethyl, chloromethyl or dichloromethyl; one of m and n is 0 or 1, and the other is 0; p is 0-4.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1218 – PubChem

 

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Synthesis of novel 6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3(2H)-one derivatives and their preliminary biological evaluation

Simple and accessible pathways for the synthesis of a series of novel 6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3(2H)-one derivatives including compounds with a combination of a pyrazolyl-pyridazine moiety with pyrimidine, 1,3,5-triazine and 1,3,4-oxadiazole rings in the same molecules were established. The tautomeric structures of 3-oxopyridazine and 5-thioxo-1,3,4-oxadiazole rings and also the position of their alkylation were shown. At preliminary screening the synthesised compounds showed pronounced plant growth stimulant activity. The most active compounds were selected for deeper studies and further field trials.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1971 – PubChem

 

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Organic Azides in Heterocyclic Synthesis, 14. Synthesis of 3,6-Diaminopyridazine from 6-Azidotetrazolo<1,5-b>pyridazine

6-Azidotetrazolo<1,5-b>pyridazine (“3,6-Diazidopyridazine”, 1) reacts at ambient temperature with phosphanes or phosphites 2a – c to yield the phosphazenes 3a – c.In contrast to literature reports, the tetrazolopyridazines 1, and 3a,b react with phosphanes to yield 3,6-bis(phosphoranylideneamino)pyridazines 4; however, the required temperature is rather high (180 deg C).The use of phosphites instead of phosphanes leads to “Michaelis-Arbuzov-type” rearrangements; thus, 3a reacts in boiling 2d to afford 6, and heating of the trimethoxyphosphazene 3c in refluxing 1,2-dichlorobenzene yields the methylamino derivative 7.Key words: Staudinger reaction / Phosphanes / Phosphites / Phosphazenes / Amidophosphonates

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1671 – PubChem

 

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COMPOUND AS GLS1 INHIBITOR

A compound as a GLS1 inhibitor as represented by formula (I) or a pharmaceutically acceptable salt thereof.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1427 – PubChem