Category: 141-30-0

Recommanded Product: 141-30-0, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article，once mentioned of 141-30-0

A TARP ?8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is; and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1322 – PubChem

You could be based in a pharmaceutical company, working on developing and trialing new drugs; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. 141-30-0

The synthesis and characterization of an alternating pyridine-pyridazine strand comprising thirteen heterocycles are described. Spontaneous folding into a helical secondary structure is based on a general molecular self-organization process enforced by the conformational information encoded within the primary structure of the molecular strand itself. Conformational control based on heterocyclic “helicity codons” illustrates a strategy for designing folding properties into synthetic oligomers (foldamers). Strong intermolecular interactions of the highly ordered lock-washer subunits of compound 3 results in hierarchical supramolecular self-assembly into protofibrils and fibrils. Compound 3 also forms mechanically stable two-dimensional Langmuir-Blodgett and cast thin films.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1663 – PubChem

Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article，once mentioned of 141-30-0

The ‘proton sponge’ – triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1668 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 3,6-Dichloropyridazine. Introducing a new discovery about 141-30-0, Name is 3,6-Dichloropyridazine

The present invention is concerned with compounds of formula STR1 the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein . dbd.a. sub.1–a 2 =a 3–a 4 = is a bivalent radical of formula . dbd.N–CH=CH–CH= (a), =CH–N=CH–CH= (b), = CH–CH=N–CH= (c), =CH–CH=CH–N= (d) , wherein one or two hydrogen atoms can be substituted by halo, hydroxy, C. sub.1-6 alkyl or C. sub.1-6 alkyloxy; R 1 is hydrogen or C 1-6 alkyl; R 2 is hydrogen or C 1-6 alkyl; R 3 is hydrogen or C. sub.1-6 alkyl; Alk. sup.1 is C 1-5 alkanediyl; Alk 2 is C 2-15 alkanediyl; Q is a five-or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula–C(NR 5 R 6). dbd.C–R 4 wherein R 4 is hydrogen, cyano, aminocarbonyl or C. sub.1-6 alkyl; R 5 is hydrogen, C 1-6 alkyl, C 3-6 alkenyl or C 3-6 alkynyl; R 6 is hydrogen or C 1-6 alkyl; or R 5 and R 6 taken together may form a bivalent radical of formula–(CH. sub. 2) 4–or–(CH 2) 5–.

Pharmaceutical compositions, preparations and use as a medicine are described.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 141-30-0 is helpful to your research.Safety of 3,6-Dichloropyridazine

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1548 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. HPLC of Formula: C4H2Cl2N2

A new series of pyrazolone-pyridazine conjugates 3 and 4a-l were synthesized and characterized by spectroscopic means and elemental analyses. All compounds were tested in vivo for their anti-inflammatory and analgesic properties against diclofenac, as reference compound. The synthesized compounds were also evaluated for their ability to inhibit the production of certain inflammatory cytokines such as TNF-alpha and IL-6 in serum samples. The ulcerogenic potential of the synthesized compounds was also determined. IC 50 values for inhibition of COX-1 and COX-2 enzymes were investigated in vitro for the most active candidates. Molecular docking was performed on the active site of COX-2 to predict their mode of binding to the amino acids. Among the synthesized derivatives, compounds 4c and 4e showed good analgesic and anti-inflammatory activities with lower ulcer index than the reference drug.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1763 – PubChem

Recommanded Product: 141-30-0, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 141-30-0

This invention relates to deuterated substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an alpha1-GABAA receptor antagonist or an alpha2- and/or an alpha3-GABAA receptor partial agonist

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 141-30-0 is helpful to your research. Recommanded Product: 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1335 – PubChem

Computed Properties of C4H2Cl2N2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article，once mentioned of 141-30-0

Ibudilast [1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one] is a nonselective phosphodiesterase inhibitor used clinically to treat asthma. Efforts to selectively develop the PDE3- and PDE4-inhibitory activity of ibudilast led to replacement of the isopropyl ketone by a pyridazinone heterocycle. Structure-activity relationship exploration in the resulting 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-ones revealed that the pyridazinone lactam functionality is a critical determinant for PDE3-inhibitory activity, with the nitrogen preferably unsubstituted. PDE4 inhibition is strongly promoted by introduction of a hydrophobic substituent at the pyridazinone N(2) centre and a methoxy group at C-7? in the pyrazolopyridine. Migration of the pyridazinone ring connection from the pyrazolopyridine 3?-centre to C-4? strongly enhances PDE4 inhibition. These studies establish a basis for development of potent PDE4-selective and dual PDE3/4-selective inhibitors derived from ibudilast.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 141-30-0 is helpful to your research.Computed Properties of C4H2Cl2N2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1596 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. Recommanded Product: 3,6-Dichloropyridazine

An N-benzoyl urea compound having the formula: STR1 wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is STR2 wherein Y1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is =CH– or a nitrogen atom, provided that one of A and B is =CH– and the other is a nitrogen atom, with the provisos (1) that when Q is STR3 where when X is a hydrogen atom and Y1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is STR4 wherein A is a nitrogen atom and Y1 is a trifluoromethyl group, Y2 is other than a hydrogen atom.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 3,6-Dichloropyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1331 – PubChem

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. HPLC of Formula: C4H2Cl2N2. Introducing a new discovery about 141-30-0, Name is 3,6-Dichloropyridazine

Compounds of formula I: where: the dashed line denotes an optional bond; R1is H, halo, alkyl, alkyloxy, amino, alkylamino, dialkylamino, or acylamino; R3and R4are independently H, halo, alkyl, alkyloxy, or hydroxy; R5is H, halo, alkyl, alkylthio, alkyloxy, alkenyloxy, alkynyl, or alkenyl; provided that at least one of R1, R3, R4, and R5is H; R7is H, alkyl, cyano, or amido; R10is a group represented by formula (A), (B), or (C); where: X is O or S; R12, R13, R15, and R16are independently H, halo, alkyl, alkyloxy, or alkylthio; and R14is H, halo, alkyl, alkylthio, alkyloxy, alkenyloxy, alkynyl, alkenyl, or -SO2R17where R17is alkyl, or -SO2NR18R19where R18and R19are independently H or alkyl; provided that at least two of R12, R13, R14, R15, and R16are H, and that if only two of R12, R13, R15, and R16are H, the non-hydrogen substituents are not all adjacent; and at least one of R12and R16is H when neither R1nor R3are H; and R20is H, alkyl, haloalkyl, hydroxyalkyl, or alkenyl; and their pharmaceutically acceptable salts, ???are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1206 – PubChem

You could be based in a pharmaceutical company, working on developing and trialing new drugs; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. Computed Properties of C4H2Cl2N2

Compounds with fungicidal and insecticidal properties having formula I STR1 wherein W is CH3 –O-A=C–CO(V)CH3 ; n is 0 or 1; A is N or CH; V is O or NH; wherein Y is O, S, NR1, or R6, the ring bond containing R4 and R5 is a single or double bond and R4 and R5 are independently selected from hydrogen and substituted or unsubstituted alkyl and aryl groups.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 141-30-0Computed Properties of C4H2Cl2N2

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1498 – PubChem