Extracurricular laboratory:new discovery of 3,6-Dichloropyridazine

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2-O-pyrimidinyl glycerol derivatives

Novel compounds having the formula: STR1 wherein STR2 represents a nitrogen-containing aromatic 6-membered ring; R1 represents a higher alkyl group which may be substituted; R2 represents a tertiary amino group or a quaternary ammonium group; and m represents 2 or 3; and salts thereof have superior antitumor activities including differentiation-inducing activity, and are useful as antitumor agents.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1358 – PubChem

 

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Related Products of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

Relative Ortho-Directing Power of Fluorine, Chlorine and Methoxy Group for the Metalation Reaction in the Diazine Series. Diazines XXXV

The regioselectivity of the metalation of 2-chloro-6-methoxypyrazine, 2-fluoro-6-methoxypyrazine and 3-fluoro-6-chloropyridazine was studied; the relative ortho-directing power was F > OMe > Cl.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1927 – PubChem

 

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Electric Literature of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent,once mentioned of 141-30-0

DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The present invention relates to compounds of formula (I) that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with d sfunction of the central nervous s stem (CNS).

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1448 – PubChem

 

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Related Products of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes

A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis. A diverse range of carboxylic acids readily undergo oxidative decarboxylation and then couple with a broad array of heteroarenes in this transformation. The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. Here we describe our effort on iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1790 – PubChem

 

Discovery of 3,6-Dichloropyridazine

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 141-30-0, name is 3,6-Dichloropyridazine. In an article,Which mentioned a new discovery about 141-30-0

B(C6F5)3-catalyzed metal-free hydrogenation of 3,6-diarylpyridazines

This paper describes the first metal-free hydrogenation of 3,6-diarylpyridazines, which was successfully realized using B(C6F5)3 as a catalyst. A variety of 1,4,5,6-tetrahydropyridazine derivatives were furnished in 85-95% yields.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1951 – PubChem

 

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Application of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent,once mentioned of 141-30-0

OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES

Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1264 – PubChem

 

Extracurricular laboratory:new discovery of 3,6-Dichloropyridazine

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METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF

The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRP mutation.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1347 – PubChem

 

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D-amino acid homopiperazine amides: Discovery of A-320436, a potent and selective non-imidazole histamine H3-receptor antagonist

Structure-activity relationships of homopiperazine-containing alkoxybiaryl nitriles employing various D-amino acid moieties and their N-furanoyl analogues were undertaken. This led to A-320436, a potent and selective non- imidazole H3-receptor antagonist possessing balanced affinity for both rat and human H3-receptors. This compound was shown to demonstrate in vitro and in vivo functional antagonism and is non-neurotoxic at doses (i.p.) up to 163 mg/kg in a general observation test.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1664 – PubChem

 

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PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS

The present invention relates to a class of compounds of general formula (I) and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R6, R7 and R10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1213 – PubChem

 

Simple exploration of 3,6-Dichloropyridazine

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. category: pyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: pyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

LIGHT EMITTING COMPOUNDS

Claimed is a cyclometallated organometallic light emitting complex having two tridentate ligand portions sharing a central heterocycle “A” providing a binding-site for each of the two metals (formula I): Formula (I): A more illustrative embodiment is formula (XII): Characterizing for the invention is that either one of XI and X2 and either one of Y1 and Y2 is carbon. The dinuclear complexes are for use in OLEDs.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1404 – PubChem