Category: 141-30-0

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 3,6-DichloropyridazineIn an article, once mentioned the new application about 141-30-0.

Compounds of formula I: where: the dashed line denotes an optional bond; R1is H, halo, alkyl, alkyloxy, amino, alkylamino, dialkylamino, or acylamino; R3and R4are independently H, halo, alkyl, alkyloxy, or hydroxy; R5is H, halo, alkyl, alkylthio, alkyloxy, alkenyloxy, alkynyl, or alkenyl; provided that at least one of R1, R3, R4, and R5is H; R7is H, alkyl, cyano, or amido; R10is a group represented by formula (A), (B), or (C); where: X is O or S; R12, R13, R15, and R16are independently H, halo, alkyl, alkyloxy, or alkylthio; and R14is H, halo, alkyl, alkylthio, alkyloxy, alkenyloxy, alkynyl, alkenyl, or -SO2R17where R17is alkyl, or -SO2NR18R19where R18and R19are independently H or alkyl; provided that at least two of R12, R13, R14, R15, and R16are H, and that if only two of R12, R13, R15, and R16are H, the non-hydrogen substituents are not all adjacent; and at least one of R12and R16is H when neither R1nor R3are H; and R20is H, alkyl, haloalkyl, hydroxyalkyl, or alkenyl; and their pharmaceutically acceptable salts, ???are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1206 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

A compound of Formula (I) or a pharmaceutically acceptable salt thereof, where R1 can be hydro, methoxy, difluoromethoxy or trifluoromethoxy; R2 can be hydro, methoxy, trifluoromethoxy or trifluoromethyl; and R3 can be hydro or methoxy. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C4H2Cl2N2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1312 – PubChem

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. SDS of cas: 141-30-0In an article, once mentioned the new application about 141-30-0.

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) [image] wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1447 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

The present invention relates to a pyrimidine derivative substituted with novel hydrazine or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and to a pharmaceutical composition for preventing or treating hyperproliferative disorders, which comprise same as an active ingredient. The present invention can be effectively used as a treatment agent for various hyperproliferative disorders related to excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy by efficiently inhibiting c-Met tyrosine kinase activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C4H2Cl2N2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1365 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 141-30-0. Introducing a new discovery about 141-30-0, Name is 3,6-Dichloropyridazine

Polycyclic derivatives of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 141-30-0, you can also check out more blogs about141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1304 – PubChem

Synthetic Route of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 141-30-0. In my other articles, you can also check out more blogs about 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1303 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 141-30-0, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 141-30-0, name is 3,6-Dichloropyridazine. In an article，Which mentioned a new discovery about 141-30-0

Abstract: Three structurally related ligands 3-chloro-6-(benzoimidazol-1-yl)pyridazine (L1), 3-chloro-6-(1,2,4-triazol-1-yl)pyridazine (L2) and 3,6-bis(imidazol-1-yl)pyridazine (L3) were designed and synthesized, and six new Zn(II), Co(II), Cu(II) and Cd(II) complexes, namely, [M(L1)2Cl2] [M = Zn (1) and Co (2)], [Cu(L2)2(NO3)2(H2O)] (3), [Cu(L2)2Cl2]? (4), [CuL3(CH3COO)2]? (5) and [CdL3(SCN)2]? (6) were synthesized and characterized by elemental analyses, IR spectra as well as single-crystal X-ray diffraction analysis. The analysis reveals that complexes 1, 2 and 3 have a mononuclear structure, 1 and 2 have a similar structure. Complex 3 features a 1D structure with intermolecular O?H?O hydrogen bonding interactions. Complex 4 shows a 1D chain structure with bridging Cl? ions. Complex 5 exhibits a 1D ladder structure. The 2D framework of 6 features are rectangular grid with a (4, 4) topology. Additionally, photoluminescence properties of ligands L1, L3 and complexes 1, 2 and 6 have been studied and discussed. Graphical Abstract: Six new metal-organic complexes were synthesized and structurally characterized, complexes 1, 2 and 3 have a mononuclear structure, complexes 4 and 5 show 1D chain structure, the 2D framework of 6 has a rectangle grid with a (4, 4) topology, moreover, photoluminescence properties of ligands L1, L3 and complexes 1, 2 and 6 have been studied and discussed. [Figure not available: see fulltext.].

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 141-30-0, help many people in the next few years.SDS of cas: 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1981 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

New alkylol derivatives are described, which belong to the class having the structure formula STR1 where R represents a 5 or 6 membered heterocyclic ring selected among pyridine, pyrimidine, pyrazine, pyridazine, thiophene, furan, thiazole which optionally may be substituted with one or more groups selected among alkyl, alkoxy, halogen, amide, hydroxy, methylthio, trifluoromethyl, cyano, carboxy and the corresponding alkyl esters and salts with alkali metals n is 2 X and X’ represent each a hydrogen atom or hydroxy group with the exception of both being hydrogen atom, and X’ may be hydroxyethoxy moiety m is 0 or 1 and the corresponding non-toxic pharmaceutically acceptable acid addition salts. The compounds of the formula I are endowed with an interesting antitussive activity and, at their active dose, practically they are free of undesired side effects.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C4H2Cl2N2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1324 – PubChem

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 141-30-0In an article, once mentioned the new application about 141-30-0.

The chelating ligands 3-chloro-6-(3-pyridyl-1-pyrazolyl)pyridazine (pp-Cl) and 3,6-bis(3-pyridyl- 1-pyrazolyl)pyridazine (bppp), were prepared by the condensation of pyridylpyrazole and 3,6-dichloropyridazine. The mononuclear complexes [(eta6-arene)Ru(pp-Cl)Cl]+ {eta6-arene = C6H 6 (1); p-iPrC6H4Me (2)}, [(eta5-C 5Me5)M(pp-Cl)]+ {M = Rh (3); Ir (4)}, [(eta6-arene) Ru(bppp)Cl]+ {eta6-arene = C6H6 (5); piPrC 6H4Me (6)}, [(eta5-C5Me5)M(bppp)]+ {M =Rh (7); Ir (8)} as well as the binuclear complexes [{(eta6- arene)RuCl}2(bppp)]2+ {eta6 -arene =C6H6 (9); p-iPrC6H4Me (10)} and [{(eta5-C5Me 5)MCl}2(bppp)]2+ {M = Rh (11); Ir (12)} have been synthesized from 3-chloro-6-(3-pyridyl-1-pyrazolyl)pyridazine (pp-Cl) or 3,6-bis(3-pyridyl-1- pyrazolyl)pyridazine (bppp) and the corresponding dimers [(eta6-arene)Ru(mu- Cl)Cl]2 and [Cp*M(mu-Cl)Cl]2, respectively. All complexes were isolated as their hexafluorophosphate salts and characterized by IR, NMR, mass spectrometry and UV-visible spectroscopy. The molecular structures of [2]PF6 and [7]PF6 have been established by single crystal X-ray structure analysis. Indian Academy of Sciences.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1600 – PubChem

Synthetic Route of 141-30-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 141-30-0, molcular formula is C4H2Cl2N2, introducing its new discovery.

The infrared and Raman spectra of 3,6-dichloropyridazine and 3,4,5-trichloropyridazine were recorded. These spectra were taken in the solid phase and with various solvents (HCCl3, CS2, CCl4), giving wavenumbers and relative intensities of the bands and the qualitative Raman depolarization ratios. Conventional ab initio methods at the Hartree-Fock and MP2 levels using the 3-21G*, 6-31G*, 6-31G*, and 6-31G*** basis sets, as well as density functional theory (DFT) using the 6-31G* basis functions and the BLYP and B3LYP functional, were used to predict the geometries and to calculate the harmonic frequencies and force fields of these molecules. In addition, coupled cluster calculations, i.e., CCSD and CCSD(T), using the 6-311G** basis set were included to evaluate the geometries of pyridazine and 3,6-dichloropyridazine, analyzing in detail the structure of these systems. To fit the calculated wavenumbers to the experimental ones, the B3LYP/6-31G* force field was selected to be scaled. The following two sets of scale factors were tested: (1) a standard set derived from a training set of 30 organic molecules (set A), and (2) a set directly calibrated from the pyridazine molecule (set B). The calculations indicate that pyridazine and its chlorinated derivatives show less aromatic character than expected. The B3LYP exchange-correlation functional with the 6-31G* basis functions gave the most reliable structural parameters for both molecules. The a priori scaled spectra were sufficiently decisive to get a complete assignment of the vibrational spectra. Both series of scale factors led to similar results. However, although the standard set (set A) proved to be an useful tool to carry out the initial assignments, further detailed analysis of the spectra required specific empirical parameters derived from the pyridazine molecule. This was especially true for the most congested spectral areas.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 141-30-0 is helpful to your research. Synthetic Route of 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1938 – PubChem