Category: 141-30-0

Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization was written by Mai, Duy N.;Baxter, Ryan D.. And the article was included in Organic Letters in 2016.Recommanded Product: 141-30-0 This article mentions the following:

An efficient and general method for the C-H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and reactivity trends reflect the nucleophilic character of the radical species generated. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 141-30-0).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Recommanded Product: 141-30-0

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors was written by Llona-Minguez, Sabin;Hoeglund, Andreas;Ghassemian, Artin;Desroses, Matthieu;Calderon-Montano, Jose Manuel;Burgos Moron, Estefania;Valerie, Nicholas C. K.;Wiita, Elisee;Almloef, Ingrid;Koolmeister, Tobias;Mateus, Andre;Cazares-Koerner, Cindy;Sanjiv, Kumar;Homan, Evert;Loseva, Olga;Baranczewski, Pawel;Darabi, Masoud;Mehdizadeh, Amir;Fayezi, Shabnam;Jemth, Ann-Sofie;Warpman Berglund, Ulrika;Sigmundsson, Kristmundur;Lundbaeck, Thomas;Jenmalm Jensen, Annika;Artursson, Per;Scobie, Martin;Helleday, Thomas. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 3,6-Dichloropyridazine This article mentions the following:

The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool “housekeeping” enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We have identified a series of piperazin-1-ylpyridazines as a new class of potent dCTPase inhibitors. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analog against leukemic cells. This new class of dCTPase inhibitors lays the first stone toward the development of drug-like probes for the dCTPase enzyme. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Recommanded Product: 3,6-Dichloropyridazine).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 3,6-Dichloropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Highly efficient Pd-PEPPSI-IPr catalyst for N-(4-pyridazinyl)-bridged bicyclic sulfonamides via Suzuki-Miyaura coupling reaction was written by Sura, Mallikarhuna Reddy;Bijivemula, N. Reddy;Pogula, Sreekanth Reddy;Motakatla, Venkata Krishna Reddy;Madhvesh, Pathak;Peddiahgari, Vasu Govardhana Reddy. And the article was included in Applied Organometallic Chemistry in 2018.Product Details of 141-30-0 This article mentions the following:

A protocol for the Suzuki-Miyaura coupling of novel 2-(6-chloropyridazin-3-yl)-5-(aryl/heteroarylsulfonyl)-2,5-diazabicyclo[2.2.1]heptanes and heteroarylboronic acids to afford variety of coupled products was realized. Pd-PEPPSI-IPr catalyst was found to be a powerful and reusable catalyst under relatively mild reaction conditions. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Product Details of 141-30-0).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Product Details of 141-30-0

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

A bifunctional small molecular photocatalyst with a redox center and a Lewis acid site for one-pot tandem oxidation-acetalization was written by Rao, Cai-Hui;Ma, Shuai;Cui, Jing-Wang;Jia, Meng-Ze;Yao, Xin-Rong;Zhang, Jie. And the article was included in Green Chemistry in 2022.Synthetic Route of C4H2Cl2N2 This article mentions the following:

By combining the double identity of a redox center and a Lewis acid site of the pyridinium derivative, the first bifunctional small mol. photocatalyst was developed for the one-pot tandem oxidation-acetalization reaction. A mechanism study revealed that pyridinium-mediated electron transfer and the photoactivation of mol. oxygen greatly facilitate the transformation of benzyl alcs. into the corresponding aldehydes, while the Lewis acid site of this bifunctional photocatalyst promoted a highly efficient acetalization reaction without any significant loss in activity after multiple reaction cycles, thus achieving the direct conversion of various alcs. into either cyclic or acyclic acetals in good yields under mild conditions without any additives. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Synthetic Route of C4H2Cl2N2).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Synthetic Route of C4H2Cl2N2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Copper-Catalyzed Bisannulations of Malonate-Tethered O-Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues was written by Miao, Chun-Bao;Guan, Hong-Rong;Tang, YiHan;Wang, Kun;Ren, Wen-Long;Lyu, Xinyu;Yao, ChangSheng;Yang, Hai-Tao. And the article was included in Organic Letters in 2021.Formula: C4H2Cl2N2 This article mentions the following:

A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes RC(=NOAc)CH₂CH(CO₂Et)₂ (R = Me, Ph, 2-furyl, etc.) with pyridine, pyrazine, pyridazine, and quinoline derivatives, e.g., 2-quinolineacetic acid, Et ester has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones, e.g., I and their analogs. The present reaction shows excellent regioselectivity and stereoselectivity. Theor. calculations reveal that the coordination effect of the carbonyl group in the nucleophilic substrate determines the excellent regioselectivity. Further functionalization of the generated dihydroindolizine-fused pyrrolidinone could be easily realized through substitution, Michael addition, selective aminolysis, and hydrolysis reactions. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Formula: C4H2Cl2N2).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Formula: C4H2Cl2N2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Highly selective and sensitive determination of copper ion based on a visual fluorescence method was written by Chen, Linfeng;Tian, Xike;Yang, Chao;Li, Yong;Zhou, Zhaoxin;Wang, Yanxin;Xiang, Fang. And the article was included in Sensors and Actuators, B: Chemical in 2017.Safety of 3,6-Dichloropyridazine This article mentions the following:

A novel ratiometric fluorescence sensor for rapid and on-site visual detection of Cu²⁺ was designed and synthesized by integrating yellow-emission rhodamine fluorophore (RL) and red-emission CdTe@SiO₂ QDs. The as-prepared nanohybrid fluorescence sensor shows dual-emissions at 537 nm and 654 nm under a single excitation at 500 nm in the presence of Cu²⁺. Owing to the strong chelating ability of RL toward Cu²⁺, the yellow fluorescence of RL could be selectively enhanced while the red fluorescence of CdTe QDs is almost unchanged, leading to an obvious fluorescence color change from red to yellow, which could be used for visual and ratiometric detection of Cu²⁺. This nanohybrid sensor exhibits excellent selectivity, sensitivity and anti-interference to Cu²⁺ detection and the detection limit is as low as 8.4 nM. Addnl., a simple device test strip for rapid and on-site detection of Cu²⁺ has been designed by immobilizing the RL-CdTe@SiO₂ QDs on a common filter paper. This simple and effective paper-based sensor has a visual detection limit of 0.5μM, showing its promising application for on-site and rapid sensing of Cu²⁺ in pollution water. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Safety of 3,6-Dichloropyridazine).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 3,6-Dichloropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of N,N-Dioxopyridazines was written by Rozen, Shlomo;Shaffer, Avshalom. And the article was included in Organic Letters in 2017.Reference of 141-30-0 This article mentions the following:

1,2-Pyridazine dioxides were prepared chemoselectively by treatment of pyridazines with HOF·MeCN (generated in situ from N₂-diluted fluorine, water, and acetonitrile) at 0°. Oxidation of 3,6-dihalopyridazines and 3-chloropyridazine with HOF·MeCN yielded only pyridazine mono-N-oxides under similar conditions. The structure of pyridazine-N,N’-dioxide was determined by X-ray crystallog. The fluorine used to prepare HOF·MeCN should be handled with appropriate precautions. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Reference of 141-30-0).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Reference of 141-30-0

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

An expeditious one-pot multicomponent synthesis of sterically hindered bis-1,2,4-triazolopyridazines under solvent-free conditions was written by Aggarwal, Ranjana;Mamta;Sumranb, Garima. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2019.Reference of 141-30-0 This article mentions the following:

A simple and ecol. facile synthesis of sterically hindered 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b:3′,4′-f]pyridazines was accomplished via a three-component reaction sequence between 3,6-dihydrazinopyridazine, an aromatic or heteroaromatic aldehydes and iodobenzene diacetate (IBD) on grinding at room temperature The 3,6-bis-arylidenehydrazinopyridazine intermediates, generated in-situ, undergo oxidative cyclization to afford the title compounds The present protocol was excellent yields, short reaction times, broad substrate scope, solvent-free greener synthesis and was an easy purification of product. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Reference of 141-30-0).

3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Reference of 141-30-0

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem