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The present invention relates to novel pyridazinyl derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.

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Pyridazine – Wikipedia,
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The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formula I) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

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Pyridazine – Wikipedia,
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Synthetic Route of 135034-10-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 135034-10-5, Name is 3-Chloro-6-iodopyridazine, molecular formula is C4H2ClIN2. In a Patent，once mentioned of 135034-10-5

The present invention is concerned with isoxazole-pyridazine derivatives of Formula (I), having affinity and selectivity for GABA A alpha 5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer¿s disease.

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Pyridazine – Wikipedia,
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A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3034 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 135034-10-5, name is 3-Chloro-6-iodopyridazine, introducing its new discovery. SDS of cas: 135034-10-5

The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3045 – PubChem

 

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Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

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Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer’s disease.

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Pyridazine – Wikipedia,
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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 3-Chloro-6-iodopyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 135034-10-5, Name is 3-Chloro-6-iodopyridazine, molecular formula is C4H2ClIN2

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-alpha protein.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 3-Chloro-6-iodopyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 135034-10-5, in my other articles.

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Pyridazine – Wikipedia,
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NVS-SM2, the first activator of pre-mRNA splicing, displays remarkable pharmacological in vivo activities in models of spinal muscular atrophy. Herein we describe an improved approach to the synthesis of this compound, which features a convenient introduction of sterically encumbered amine moiety onto a fluoropyridazine intermediate.

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Pyridazine – Wikipedia,
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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C4H2ClIN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 135034-10-5, name is 3-Chloro-6-iodopyridazine. In an article，Which mentioned a new discovery about 135034-10-5

CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to a class of substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (Formula (I))

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Reference：
Pyridazine – Wikipedia,
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