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Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3051 – PubChem

 

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Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer’s disease.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3056 – PubChem

 

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135034-10-5, Name is 3-Chloro-6-iodopyridazine, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 135034-10-5.

Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3073 – PubChem

 

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The present disclosure a Syk compound inhibitors, including state cancer and inflammation and various disease States thereof in the treatment of relates to the use of. In one aspect a particular embodiment, . given by formula I which is marked as a chemical structure of compound. In formula said, X 1, X 2, X 3, R 2, R 3, R 4, R 5, and Y has described herein is. The present disclosure of a formula I compounds or a pharmaceutically acceptable salt of pharmaceutical compositions including, mediated by Syk and to treat conditions a employing these compounds and compositions further provides a method. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 3-Chloro-6-iodopyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 135034-10-5, in my other articles.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3039 – PubChem

 

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The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2¿, R3, R3¿, R4, R4¿, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3048 – PubChem

 

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Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3040 – PubChem

 

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Reference of 135034-10-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 135034-10-5, Name is 3-Chloro-6-iodopyridazine, molecular formula is C4H2ClIN2. In a Patent,once mentioned of 135034-10-5

Compounds of the formula (I), in which Y, R1, R2, R3 and R3? have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3059 – PubChem

 

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A first principle study of the cross-coupling reaction between 3-chloro-6-iodopyridazine and triphenylbismuth under palladium catalysis has been carried out. The approach selected for this investigation is the density functional theory within the framework of the PBE0 and B3LYP hybrid exchange?correlation functionals, with and without including empirical corrections for the dispersion forces at the GD3 level. For this reaction, a three-step mechanism including an oxidative addition, a transmetalation and a reductive elimination has been proposed. All intermediates and transition states have been fully characterized. The energy profile is deduced in gas phase and in solvent. Calculations suggest that the oxidative addition is the rate-determining step for the entire cross-coupling reaction.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3066 – PubChem

 

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The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3058 – PubChem

 

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The present invention relates to linear pyridazine compounds, and more particularly to those of these compounds which are oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to pyrroles and to the uses of the pyrrole, pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the applications in the materials, environmental, electronics and optics field.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3041 – PubChem