Category: 13327-27-0

Reference of 13327-27-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article£¬once mentioned of 13327-27-0

Pyridazinones. 3. Synthesis, Antisecretory, and Antiulcer Activities of 2-Cyanoguanidine Derivatives

3(2H)-Pyridazinone derivatives having a 2-cyanoguanidine moiety, as well as a sulfur or an oxygen atom in the alkylene side chain, were synthesized and evaluated for gastric antisecretory and antiulcer activities.The key intermediates, free amines having a thioether linkage, were synthesized by the reaction of 2-(omega-chloroalkyl)derivatives with cysteamine, while other intermediates having an ether linkage were synthesized from 2-(omega-chloroalkyl)oxymethyl derivatives.These free amines were converted via the 3-cyano-2-methyl-1-isothiourea derivatives into the desired 2-cyano-3-substituted-1-guanidine derivatives.All compounds synthesized were evaluated for gastric antisecretory activity in the pylorus-ligated rat by the method of Shay, and selected compounds were evaluated in the stress-induced ulcer test in rat.Structure-activity relationships are discussed.The molecular features for the best activities are a phenyl group in the C-6 position of the 3(2H)-pyridazinone ring, a four-atom chain length between the 3(2H)-pyridazinone ring and the 2-cyanoguanidine moiety, and a thioether rather than an ether linkage.Among them, compound 14, 2-<<<2-(2-cyano-3-methyl-1-guanidino)ethyl>thio>methyl>-6-phenyl-3(2H)-pyridazinone, had the most potent antisecretory and antiulcer activities.These compounds are neither histamine H2 receptor inhibitors nor anticholinergic agents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 13327-27-0. In my other articles, you can also check out more blogs about 13327-27-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N330 – PubChem

 

Synthetic Route of 13327-27-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 13327-27-0, 6-Methylpyridazin-3(2H)-one, introducing its new discovery.

Synthesis of 3-Alkynylpyridazines from 3-Trifluoromethanesulfonylpyridazines

An efficient synthesis of 3-alkynylpyridazines starting from the pyridazine triflates using a Pd0 cross-coupling reaction is described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 13327-27-0. In my other articles, you can also check out more blogs about 13327-27-0

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Pyridazine | C4H4N328 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 13327-27-0, name is 6-Methylpyridazin-3(2H)-one, introducing its new discovery. Quality Control of 6-Methylpyridazin-3(2H)-one

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system. The Royal Society of Chemistry 2009.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N304 – PubChem

 

Related Products of 13327-27-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article£¬once mentioned of 13327-27-0

PREPARATION AND REACTIONS OF SOME 2-THIENYL AND 3-THIENYL PYRIDAZINONES AND PYRIDAZINES

The preparation and reactions of some pyridazinone derivatives with 2- and 3-thienyl substituents are described.Precursor 4-oxobutanoic acids Ar2COCH2CH(Ar1)CO2H (Ar1=Pb, Ar2=2-thienyl and Ar1=2-thienyl, Ar2=Pb) were obtained by addition of HCN to the chalcones Ar1CH=CHCOAr2 followed by acid hydrolysis of the resulting nitrile.Nitriles, ArCOCH(CH3)CH2CN were prepared by the Michael-Stetter reaction and converted via the acids to the 4,5-dihydropyridazin-3(2H)-ones.Two methods wereused to obtain pyridazin-3(2H)-ones viz oxidation of the 4,5-dihydro derivatives with selenium dioxide and base-catalyzed condensation of methanal or aryl aldehydes at the 4-position of the 4,5-dihydro compound.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N323 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 13327-27-0, name is 6-Methylpyridazin-3(2H)-one, introducing its new discovery. name: 6-Methylpyridazin-3(2H)-one

Malononitrile compounds as pesticides

The present invention provides a malononitrile compound represented by the formula (I):The malononitrile compound has an efficient pesticidal activity and can control effectively pests.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N289 – PubChem

 

Related Products of 13327-27-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article£¬once mentioned of 13327-27-0

Pyridazinones. 2. Synthesis and Antisecretory and Antiulcer Activities of Thiourea and 2-Cyanoguanidine Derivatives

In an effort to develop new types of antiulcer agents, we synthesized a series of novel 2-– and 2--3-(2H)-pyridazinone derivatives.All target compounds were evaluated for gastric antisecretory activity in the pylorus-lygated rat by the method of Shay, and selected compounds were evaluated in the stress-induced ulcer test in rats.Structure-activity relationships were esthablished.Two series of the compounds had significant activity in antisecretory and/or antiulcer tests.The molecular features essential for the activities are a thiourea group or a 2-cyanoguanidine group, a phenyl group in the C-6 position of the 3(2H)-pyridazinone ring, a four-carbon chain length between the 3(2H)-pyridazinone ring and the functional group, and a methyl group at the N-3 position of the functional group.Among them, the three thiourea derivatives (24, 26, and 38) and the six 2-cyanoguanidine derivatives (61,62,65,75,85, and 86) had the most potent antisecretory and/or antiulcer activities.These compounds are not histamine H2-receptor antagonists.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N329 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Filipski, Kevin J. and a compound is mentioned, 13327-27-0, 6-Methylpyridazin-3(2H)-one, introducing its new discovery. 13327-27-0

A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C-N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of functionality on both the aryl halide and pyridin-2-one reactants and have resulted in numerous examples being synthesized.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N308 – PubChem

 

13327-27-0, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 13327-27-0

BROMODOMAIN INHIBITORS

Provided herein are compounds of formula (I) wherein R 1, Y, L 1, G 1, X 1, X 2, L 2, R 2, R 3, and R 4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N282 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13327-27-0,6-Methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

13327-27-0, 6-Methylpyridazin-3(2H)-one (Alfa, 2.5 g, 22.70 mmol) and phosphorus oxybromide (Aldrich, 16.27 g, 56.8 mmol) were heated at 90 C under a nitrogen atmosphere for 1.5 hours. After cooling, the mixture was poured onto ice (100 g), neutralized with sodium bicarbonate, and the aqueous phase was extracted with CH2Cl2 (3chi30 mL). The combined organic phase was washed with 5% NaHCO3, brine, dried (Na2SO4) and concentrated. The residue was dissolved in hot ethyl acetate and washed through a plug of silica gel, eluting with ethyl acetate and concentrated. MS (DCI/NH3) m/z 172 (M+H)+, 190 (M+NH4)+.

13327-27-0 6-Methylpyridazin-3(2H)-one 83346, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; SCHRIMPF, Michael R.; LEE, Chih-Hung; LI, Tao; GFESSER, Gregory A.; MORTELL, Kathleen H.; FAGHIH, Ramin; NERSESIAN, Diana L.; SIPPY, Kevin B.; BUNNELLE, William H.; SCANIO, Marc; SHI, Lei; GOPALAKRISHNAN, Murali; DONNELLY-ROBERTS, Diana; HU, Min; WO2010/36998; (2010); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13327-27-0,6-Methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

To 6-methylpyridazin-3(2H)-one (0.510 g, 4.63 mmol) was added 5 N sodium hydroxide solution (1.85 mL) followed by 2-bromopropanoic acid (0.709 g, 4.63 mmol). The reaction mixture was heated at 90 C. for 1 h. After cooled down to ambient temperature, 2 M hydrochloric acid (5.0 mL) was added and the reaction mixture was directly purified by reverse phase HPLC (TMC Pro-Pac C18; 8-20% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient). The O-alkylation product was eluted fast. The pure fractions were collected and lyophilized overnight to afford the two title compounds. LC/MS 183.2 (M+1). 2-[3-methyl-6-oxopyridazin-1(6H)-yl]propanoic acid (i-42): 1H NMR (DMSO-d6): delta 7.34 (d, J=9.7 Hz, 1H), 6.88 (d, J=9.4 Hz, 1H), 5.30 (q, J=7.3 Hz, 1H), 2.26 (s, 3H), 1.49 (d, J=7.3 Hz, 3H). 2-[(6-methylpyridazin-3-yl)oxy]propanoic acid (i-43): 1H NMR (DMSO-d6): delta 8.36 (d, J=9.0 Hz, 1H), 7.90 (d, J=9.2 Hz, 1H), 6.00 (q, J=6.6 Hz, 1H), 2.90 (s, 3H), 1.73 (d, J=6.6 Hz, 3H)., 13327-27-0

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Reference£º
Patent; Berger, Richard; Chang, Lehua; Edmondson, Scott D.; Goble, Stephen D.; Ha, Sookhee Nicole; Kar, Nam Fung; Kopka, Ihor E.; Li, Bing; Morriello, Gregori J.; Moyes, Chris R.; Shen, Dong-Ming; Wang, Liping; Zhu, Cheng; US2009/253705; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem