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The present invention provides benzoxazinones of formula I wherein R1 is hydrogen or halogen; R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl, C3-C6-haloalkynyl, C1-C6-alkoxy or C3- C6-cycloalkyl-C1-C6-alkyl; R3 is halogen; R4 is halogen; X is O or S; and Y is a substituted or unsubstituted heterocycle; Benzoxazinones of formula I are useful as herbicides.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2166 – PubChem

 

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The present invention relates to new dithiinopyridazinedione derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these dithiinopyridazinedione derivatives.

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The preparation method comprises the following steps: firstly, reacting formic acid with hydrazine hydrate; then, reacting formic acid with hydrazine hydrate to generate N,N ? – tetrahydropyridazine-1, 2-N,N ? – diformaldehyde; finally, reacting tetrahydropyridazine-1, 1, 4 – 2-diformaldehyde with hydrochloric acid to form a hexahydropyridazine dihydrochloride. Compared with the prior art, compared with the prior art, the method has the advantages of easily available raw materials, low cost, mild reaction, simple operation, low requirement on reaction equipment and easy industrialization. (by machine translation)

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Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. HPLC of Formula: C4H12Cl2N2

The invention provides compounds of Formula I or Formula II: (I), (II) or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections

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Reference:
Pyridazine – Wikipedia,
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The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research.Keep reading other articles of pyridazineApplication of 124072-89-5

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. Application of 124072-89-5. Introducing a new discovery about 124072-89-5, Name is Hexahydropyridazine dihydrochloride

The invention relates to hetaryl-substituted pyrazolidindione derivatives of formula (I), in which Het, A, D and G have the meanings cited in the description, to a number of methods for the production thereof, and to their use as pesticides and/or herbicides. The invention also relates to selective herbicidal agents that contain hetaryl-substituted pyrazolidindione derivatives and a compound that improves compatibility with cultivated plants.

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The present invention relates to compounds which are of use in the field of agriculture as herbicides. The compounds in question are of formula II and comprise a spirofused tricycle core: wherein R4 and R5 together with the carbon atom to which they are attached form a cyclic group.

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The present invention relates to Arylmethylidene heterocycles, compositions comprising an Arylmethylidene heterocycle, and methods useful for treating or preventing pain comprising administering an effective amount of an Arylmethylidene heterocycle as depicted by the formula (Ia).The compounds, compositions, and methods of the invention are also useful for treating or preventing inflammation.

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Cathepsin K is the key regulator in the osteoclast-mediated bone resorption. Here, we found the correlation between the inhibitory activities of carbonitrile derivatives in the enzymatic activity of cathepsin K and their binding scores predicted using FlexX-Pharm docking program. The binding pattern of [1-(2-cyano-tetrahydro-pyridazine-1-carbonyl)-2-methy-propyl]-carbamic acid benzyl ester (8), one member of this series, was similar to that of the reference. In a bone pit formation assay, compound 8 was shown to dose-dependently inhibit the bone resorptive activity of mature osteoclasts.

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Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-selective MTHFD2 inhibitor is highly attractive for potential use in cancer treatment. Herein, we disclose a novel isozyme-selective MTHFD2 inhibitor DS44960156, with a tricyclic coumarin scaffold, which was initially discovered via high-throughput screening (HTS) and improved using structure-based drug design (SBDD). DS44960156 would offer a good starting point for further optimization based on the following features: (1) unprecedented selectivity (>18-fold) for MTHFD2 over MTHFD1, (2) a molecular weight of less than 400, and (3) good ligand efficiency (LE).

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Pyridazine – Wikipedia,
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The present disclosure relates to a composition for dyeing keratin fibers, for instance human keratin fibers such as the hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolone compounds and addition salts thereof, at least one coupler and at least one C4-C30 polyol. The present disclosure also relates to the dyeing process and kit using the composition as presently disclosed. Use of the present disclosure makes it, for example, possible to obtain fast coloration of keratin fibers that is resistant to light and to washing.

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Pyridazine – Wikipedia,
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