With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123696-02-6,3-Chloro-5-methoxypyridazine,as a common compound, the synthetic route is as follows.
A degassed solution of 3-chloro-5-methoxypyridazine (473 mg, 3.27 mmol), 3,5-difluoro-4-trimethylstannanylpyridine (1.0 g, 3.6 mmol), copper [(I)] iodide (31 mg, 0.2 mmol) and lithium chloride (416 mg, 9.8 mmol) was formed in 1,4-dioxane (10 ml). Tetrakis (triphenylphosphine)- palladium [(0)] (100 mg) was added and the mixture heated to [80C] for 16 h. The solvent was removed and the residue was purified by flash column chromatography over silica using 40% isohexane: 60% ethyl acetate to give 3- (3, 5-difluoropyridin-4-yl)-5-methoxypyridazine as a pale yellow solid (220 mg): 8H (400 MHz, [CDCL3)] 7.10-7. 12 [(1H,] m), 8. 54 (2H, s), 9.02 [(1H,] d, [J 3.] 1); [7NLZ] (ES+) 224.
123696-02-6, 123696-02-6 3-Chloro-5-methoxypyridazine 10975612, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2004/14865; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem