Category: 1228788-25-7

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A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body’s production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I , or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1228788-25-7 is helpful to your research. Reference of 1228788-25-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1131 – PubChem

 

Synthetic Route of 1228788-25-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1228788-25-7, Name is Pyridazin-3-ylmethanamine hydrochloride, molecular formula is C5H8ClN3. In a Patent，once mentioned of 1228788-25-7

This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1228788-25-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1133 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 1228788-25-7, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1228788-25-7

The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body”s production of cyclic guanosine monophosphate (“”cGMP””) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1132 – PubChem

 

Application of 1228788-25-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1228788-25-7, molcular formula is C5H8ClN3, introducing its new discovery.

no abstract published

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1228788-25-7 is helpful to your research. Application of 1228788-25-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1129 – PubChem

 

1228788-25-7, Name is Pyridazin-3-ylmethanamine hydrochloride, belongs to pyridazine compound, is a common compound. Formula: C5H8ClN3In an article, once mentioned the new application about 1228788-25-7.

CANCER TREATMENTS TARGETING CANCER STEM CELLS

Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O’), and (I):

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1130 – PubChem

 

Reference of 1228788-25-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1228788-25-7, molcular formula is C5H8ClN3, introducing its new discovery.

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body’s production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I , or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1228788-25-7 is helpful to your research. Reference of 1228788-25-7

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1131 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228788-25-7,Pyridazin-3-ylmethanamine hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of 2,3,6-trifluorophenyl acetic acid (5.5 g, 29 mmol) and the intermediate from Step C (5.0 g, 34 mmol) in DCM (20 mL) was added EDC (7.9 g, 41.2 mmol) followed by DIEA (17.99 mL, 103 mmol). After stirring the reaction at room temperature for 18 hours, it was diluted with DCM (100 mL), and washed with water (2X). The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a brown solid. LC3 rt = 0.6 min, m/z = 282 (M+H)., 1228788-25-7

1228788-25-7 Pyridazin-3-ylmethanamine hydrochloride 53419881, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; BROCKUNIER, Linda, L.; GUO, Jian; PARMEE, Emma, R.; RAGHAVAN, Subharekha; ROSAUER, Keith; STELMACH, John, E.; SCHMIDT, Darby Rye; (87 pag.)EP2373317; (2016); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem