Category: 121163-50-6

Tucker, John A. et al. published their research in Journal of Medicinal Chemistry in 1998 | CAS: 121163-50-6

N-(3,6-Dichloropyridazin-4-yl)acetamide (cas: 121163-50-6) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Formula: C6H5Cl2N3O

Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring was written by Tucker, John A.;Allwine, Debra A.;Grega, Kevin C.;Barbachyn, Michael R.;Klock, Jennifer L.;Adamski, Jenifer L.;Brickner, Steven J.;Hutchinson, Douglas K.;Ford, Charles W.;Zurenko, Gary E.;Conradi, Robert A.;Burton, Phillip S.;Jensen, Randy M.. And the article was included in Journal of Medicinal Chemistry in 1998.Formula: C6H5Cl2N3O This article mentions the following:

Oxazolidinones are a novel class of synthetic antibacterial agents active against gram-pos. organisms including methicillin-resistant Staphylococcus aureus as well as selected anaerobic organisms. Important representatives of this class include the morpholine derivative linezolid, which is currently in phase III clin. trials, and the piperazine derivative eperezolid. As part of an investigation of the structure-activity relationships of structurally related oxazolidinones, we have prepared and evaluated the antibacterial properties of a series of piperazinyl oxazolidinones in which the distal nitrogen of the piperazinyl ring is substituted with a six-membered heteroaromatic ring. Compounds having MIC values ≤ 2 μg/mL vs. selected gram-pos. pathogens were discovered among each of the pyridine, pyridazine, and pyrimidine structural classes. Among these the cyanopyridine I, the pyridazines II and III, and the pyrimidine IV exhibited in vivo potency vs. Staphylococcus aureus comparable to that of linezolid. In the experiment, the researchers used many compounds, for example, N-(3,6-Dichloropyridazin-4-yl)acetamide (cas: 121163-50-6Formula: C6H5Cl2N3O).

N-(3,6-Dichloropyridazin-4-yl)acetamide (cas: 121163-50-6) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Formula: C6H5Cl2N3O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem