Category: 1211591-88-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

To a solution of 2-[6-(2-bromoacetyl)-5-ethylsulfonyl-3-pyridyl]-2-methyl-propanenitrile (300 mg, 0.84mmol, 1.00 equiv.) [compound 12 prepared as described in step 2, example P1] in acetonitrile (6.3 mL)were added 5-(trifluoromethyl)pyridazine-3-amine (150 mg, 0.88 mmol, 1.00 equiv.) [prepared asdescribed in W02016/051193) and magnesium oxide (67 mg, 1.70 mmol, 2.00 equiv.) at roomtemperature under argon atmosphere. The resulting mixture was heated to 90 C overnight. The reaction mixture was cooled down at room temperature, filtered and concentrated. The crude material was diluted with ethyl acetate and satuared ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate. The organic layers were combined, dried overanhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel (ethyl acetate in cyclohexane) to obtain the title compound. LCMS (method 4): 424 (M+H) retention time: 0.97 mm., 1211591-88-6

The synthetic route of 1211591-88-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; RENDLER, Sebastian; EDMUNDS, Andrew; MUEHLEBACH, Michel; EMERY, Daniel; RAWAL, Girish; SEN, Indira; SIKERVAR, Vikas; (105 pag.)WO2019/53182; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

82 mg of 5-(trifluoromethyl)pyridazin-3-amine was dissolved in 5 ml of chlorobenzene, and 20 mg of 2-bromo-1-[3-(ethylsulfonyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]ethanone was added at room temperature. After the addition, the reaction mixture was stirred under reflux with heating for 3 hours. After the reaction, the reaction mixture was mixed with 10 ml of a 1M sodium hydroxide aqueous solution and extracted with ethyl acetate (10 ml*2). The obtained organic layer was dehydrated with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by preparative medium pressure liquid chromatography using n-hexane/ethyl acetate (with a gradient of from 10:0 to 0:10) as the eluent to obtain 142 mg of the desired product as a brown solid. Melting point: 214-218 C. 1H-NMR (CDCl3): delta9.40 (d, J=7.5 Hz, 1H), 8.94 (s, 1H), 8.58 (d, J=2.0 Hz, 1H), 8.34-8.30 (m, 1H), 8.11-8.09 (m, 1H), 7.24 (dd, J=7.5, 2.0 Hz, 1H), 3.79 (q, J=7.4 Hz, 2H), 1.36 (t, J=7.4 Hz, 3H)., 1211591-88-6

1211591-88-6 5-(Trifluoromethyl)pyridazin-3-amine 67123099, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Nissan Chemical Industries, Ltd.; KUDO, Takao; MAIZURU, Yukihiro; TANAKA, Ayano; NOTO, Kenkichi; MATSUI, Hiroto; KOBAYASHI, Masaki; (260 pag.)US2018/22760; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

The compound 3 (26 mg) and the compound 6 (14 mg) were dissolved in DMF (1 ml) followed by the addition of sodium bicarbonate (7 mg) thereto, and the mixed solution was stirred at 80 C. for 20 h. After the solution was diluted with ethyl acetate, the solution was washed sequentially with water and a saturated saline. After the organic layer was dried with anhydrous sodium sulfate, the organic layer was filtrated. After the organic layer was concentrated, the residue was purified by the silica gel column chromatography affording the compound 4 (2.6 mg).MS m/z 372 [M+H]+, APCI(+)

1211591-88-6, As the paragraph descriping shows that 1211591-88-6 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Tanage Pharma Corporation; US2012/258951; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem