Category: 1122-63-0

New learning discoveries about 1122-63-0

As the paragraph descriping shows that 1122-63-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-63-0,1-(Pyridazin-3-yl)ethanone,as a common compound, the synthetic route is as follows.

Step 1 1-Methoxy-2-(pyridazin-3-yl)propene Prepared according to the method of Example 12, Step 1, using 3-acetylpyridazine. 1 H NMR (360 MHz, CDCl3) delta 2.15 (3H, d, J=1.3 Hz), 3.78 (3H, s), 6.49 (1H, d, J=1.2 Hz), 7.33 (1H, dd, J=8.8 and 4.8 Hz), 8.16 (1H, dd, J=8.8 and 1.6 Hz), 8.95 (1H, dd, J=4.8 and 1.6 Hz)., 1122-63-0

As the paragraph descriping shows that 1122-63-0 is playing an increasingly important role.

Reference£º
Patent; Merck Sharp & Dome Ltd.; US5973156; (1999); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

Brief introduction of 1122-63-0

The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.

1122-63-0, 1-(Pyridazin-3-yl)ethanone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1122-63-0, [Referential Example 13] Lithium 1-(6-methoxy-3-pyridyl)-5-(3-pyridazinyl)-1H-pyrazole-3-carboxylate; [Show Image] 1) Methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate; A 1.0M solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (19 ml) was added dropwise to a solution of 3-acetylpyridazine (2.097 g) in tetrahydrofuran (50 ml) under argon atmosphere at -78C, and the mixture was stirred for 1 hour. A solution of dimethyl oxalate (4.055 g) in tetrahydrofuran (35 ml) was added dropwise to the reaction liquid, and the mixture was stirred at 0C for 2 hours. The reaction solvent was evaporated under reduced pressure, and water and diethylether were added to the residue, then the aqueous layer was separated. The aqueous layer was then acidified with 1N aqueous hydrochloric acid, and the solution was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate (2.63 g, 73%) as a solid. 1H-NMR (400 MHz, CDCl3)delta: 3.97 (3H, s), 7.73 (1H, dd, J = 8.5, 5.1 Hz), 7.96 (1H, s), 8.28 (1H, dd, J = 8.5, 1.8 Hz), 9.38 (1H, dd, J = 5.1, 1.8 Hz). ESI-MSm/z: 209 (M+H)+.

The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1698626; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

Analyzing the synthesis route of 1122-63-0

The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-63-0,1-(Pyridazin-3-yl)ethanone,as a common compound, the synthetic route is as follows.

Triisopropylsilyl triflate (26.4 g) is added over 4 min. to an ice cooled solution [OF 3-] acetylpyridazine (9.57 g) and diisopropylethylamine [(30.] 4 g) in dry [CH2C12] [(100 ML)] under nitrogen. After 4 h, the solvent is evaporated and the residue extracted with diethyl ether (150 mL). The organic layer is washed with saturated aq. sodium bicarbonate solution (2 [X] [60] mL) followed by brine (60 [ML),] dried [(MGSO4),] filtered and evaporated.. The crude product is purified by column chromatography [(HEXANES/ETOAC,] 9/1) to afford 13.4 g of the title compound as a yellow oil. Physical [CHARACTERISTICS. 1H NMR (400 MHz, CDCl3) delta 9.10, 7.85, 7.52, 5.98, 4.74, 1.35, 1.16 ; HRMS (ESI) m/z 279.1879

The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; FLECK, Bruce, Francis; WO2004/22567; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem