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By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this exploration, a facile decarboxylation was noted and was exploited as a novel prodrug mechanism. The synthesis and characterization of these prodrugs and their utilization in chronic toxicity studies are presented.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N672 – PubChem

 

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(Chemical Equation Presented) A general efficient electrochemical method for the preparation of aryl- and heteroarylpyridazines in a nickel-catalyzed cross-coupling reaction of 3-chloro-6-methoxypyridazine and 3-chloro-6- methylpyridazine with a range of functionalized aryl or heteroaryl halides is reported.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N696 – PubChem

 

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The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 ss-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N568 – PubChem

 

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Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

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Pyridazine – Wikipedia,
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1121-79-5, Name is 3-Chloro-6-methylpyridazine, belongs to pyridazine compound, is a common compound. COA of Formula: C5H5ClN2In an article, once mentioned the new application about 1121-79-5.

A mild, practical method for direct arylation of unactivated C(sp3)-H bonds with heteroarenes has been achieved via photochemistry. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation. A diverse range of chemical feedstocks, such as alkanes, ketones, esters, and ethers, and complex molecules readily undergo intermolecular C(sp3)-C(sp2) bond formation. Moreover, a broad array of heteroarenes, including pharmaceutically useful scaffolds, can be alkylated effectively by the protocol presented here.

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Pyridazine – Wikipedia,
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The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S configuration and the substituents X and R1-R9 are as defined herein.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N600 – PubChem

 

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Compounds of the formula STR1 wherein B is –C C– or –CH2 CH2 –, R1 is straight-chain C1 -C12 -alkyl and R2 is straight-chain C1 -C12 -alkyl or straight-chain C1 -C12 -alkoxy, their manufacture and use in liquid crystalline mixtures are described.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N615 – PubChem

 

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Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce the excessive activation of complement.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N640 – PubChem

 

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The present invention relates to crystalline compounds of the following structural formula (II) possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 beta -hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N569 – PubChem

 

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The reactions of methylhydrazine and hydrazine hydrate with chlorinated pyridazines and pyridazones were studied.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N648 – PubChem