Category: 1121-79-5

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 4-(6-Chloro-pyridazin-3-yl)-cvclopropanecarbonitrileStep 1 : 3-chloro-6-chloromethyl-pyridazine; Trichloroisocyanuric acid (3.62 g) was added to a solution of 3-chloro-6-methyl-pyridazine (5.00 g) in chloroform (130 mL) heated to 60 C. The mixture was stirred at 60 1121-79-5

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; XU, Zhenrong; HIMMELSBACH, Frank; ECKHARDT, Matthias; WO2011/159760; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

A. To a mechanically stirred solution of 3-chloro-6-methylpyridazine (155.6 mmol) in 140 mL of concentrated sulfuric acid, finely powdered potassium dichromate (55.40 g) was added slowly, the temperature being kept below 50 C. When the addition was complete, stirring was continued for another 4 hours at 50 C. The viscous, dark green liquid was then cooled and crushed ice was added cautiously. The reaction mixture was extracted with ethyl acetate (6*400 mL). The ethyl acetate extracts were combined, dried over anhydrous Na2SO4. The solvent was concentrated in vacuo to yield slightly red colored 6-chloropyridazine-3-carboxylic acid (106.6 mmol). This material was used for next reaction without further purification. Yield 69%. m.p. 145 C. (dec). 1H NMR (300 MHz, DMSO-d6) delta 13.1, 8.20, 8.05., 1121-79-5

The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; US2008/207587; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Chloro-pyridazine-3-carboxylic Acid A mixture of 3-chloro-6-methyl-pyridazine (10.0 g, 77.8 mmol) and K2Cr2O7 (38.1 g, 128 mmol) in conc. H2SO4 (150 ml) was heated to 60 C. for 24 h. The mixture was poured onto ice/water and extracted with EtOAc. The combined org. layers were then concentrated in vacuo and then taken up in EtOAc. The suspension was filtered and dried in vacuo to give 6-chloro-pyridazine-3-carboxylic acid (80% pure, 4.1 g, 27%). UPLC (5-100% CH3CN): tR=0.523 min, MS (ES-): 157 [M-1]., 1121-79-5

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; Glatthar, Ralf; Carcache, David; US2009/105266; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Add trichloroisocyanuric acid (0.189 g) to a solution of 3-chloro-6-methylpyridazine (0.208 g) in chloroform (10 mL). Heat the oil bath to 60 C, lasts for 12 hours. Cool to room temperature, the filtrate was collected by filtration. Concentrated and purified by column chromatography (PE/EA=10/1). 0.201 g of 3-chloro-6-(chloromethyl)pyridazine was obtained.

The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BetaEpsilonTauTauAlpha PHARMACEUTICALS CO., LTD; WANG, YIQIAN; WANG, JIABING; DING, LIEMING; (80 pag.)TW2018/29406; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Step 1. 3-Chloro-6-chloromethyl-pyridazine To a solution of 3-chloro-6-methyl-pyridazine (25 g, 0.2 mol) in chloroform (850 mL) at 60 C. was added trichloroisocyanuric acid (0.4 eqivalent, 18.1 mol) and stirred for 15 hours. An additional charge of trichloroisocyanuric acid (3 g) was added and the mixture heated for an additional hour. The mixture was then cooled in an ice bath and filtered over celite. The organic solution was concentrated to a yellow oil which darkened and solidified upon standing in the freezer (yield 30 g, 95%).

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; Leivers, Martin Robert; Lauchli, Ryan; US2010/29655; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Step 1. 3-Chloro-6-chloromethyl-pyridazine To a solution of 3-chloro-6-methyl-pyridazine (25 g, 0.2 mol) in chloroform (850 mL) at 60 C. was added trichloroisocyanuric acid (0.4 eqivalent, 18.1 mol) and stirred for 15 hours. An additional charge of trichloroisocyanuric acid (3 g) was added and the mixture heated for an additional hour. The mixture was then cooled in an ice bath and filtered over celite. The organic solution was concentrated to a yellow oil which darkened and solidified upon standing in the freezer (yield 30 g, 95%).

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; Leivers, Martin Robert; Lauchli, Ryan; US2010/29655; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

To a refluxing solution of 3-chloro-6-methylpyridazine (5.0 g, 39 mmol) in chloroform (75 mL) was added trichloroisocyanuric acid (3.6 g, 16 mmol) portionwise. The solution was allowed to reflux overnight, after which the crude reaction mixture was filtered, washed with 1 M sodium hydroxide (NaOH), and the organic phase was dried over magnesium sulfate. The crude product was concentrated under reduced pressure and purified by silica gel chromatography to furnish 3-chloro-6-chloromethyl-pyridazine (D) as a yellow oil which upon sitting became a brown solid=2.9 g (46%).

1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; DOW AGROSCIENCES LLC; US2010/56534; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add trichloroisocyanuric acid (0.189 g) to a solution of 3-chloro-6-methylpyridazine (0.208 g) in chloroform (10 mL). Heat the oil bath to 60 C, lasts for 12 hours. Cool to room temperature, the filtrate was collected by filtration. Concentrated and purified by column chromatography (PE/EA=10/1). 0.201 g of 3-chloro-6-(chloromethyl)pyridazine was obtained.

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; BetaEpsilonTauTauAlpha PHARMACEUTICALS CO., LTD; WANG, YIQIAN; WANG, JIABING; DING, LIEMING; (80 pag.)TW2018/29406; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 14 6-Chloro-3-chloromethylpyridazine A suspension of 3-chloro-6-methylpyridazine (3 g), benzoyl peroxide (150 mg) and N-chlorosuccinimide (3.12 g) in CCl4 (30 ml) was refluxed 16 hours, cooled, filtered and evaporated. Chromatography (EtOAc/hexane) gave title compound (1.67 g). NMR delta (CDCl3) 4.87 (2H, s), 7.58 (1H, d), 7.71 (1H, d).

1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; Aitken, Steven; Brooks, Gerald; Dabbs, Steven; Frydrych, Colin Henry; Howard, Steven; Hunt, Eric; US2004/58937; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Intermediate A1 3-Methyl-6-[4-(methylsulfonyl)phenyl]pyridazineA suspension of 3-chloro-6-methylpyridazine (1.0 g, 7.78 mmol), (4-methylsulfonyl-phenyl)boronic acid (1.71 g, 8.56 mmol), Pd(PPh3)4 (450 mg, 0.39 mmol), potassium carbonate (2.69 g, 19.45 mmol) in 1,4-dioxane (25 mL) and water (5 mL) was heated at 95 C. overnight. Upon evaporation of the solvents, the residue was partitioned between water (150 mL) and chloroform (150 mL). The layers were separated and the water phase was extracted with chloroform (2 100 mL). The combined organic layers were evaporated and purified by flash chromatography (1:1 DCM/EtOAc, then 100% EtOAc). Yield 1.36 g (70%); Analytical HPLC: purity 99% (System A, RT=1.04 min); LRESIMS for C12H12N2O2S m/z 249 (M+H)+.

The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum; US2008/58339; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem