Category: 1120-88-3

1120-88-3, 4-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 4-Methyl-pyridazine (11) (0.500 g, 5.312 mmol) and Benzaldehyde (12) (1.1 g, 10.625 mmol) was added zinc chloride (1.44 g, 10.625 mmol) and the resultant reaction mixture was heated at 150C for 16h. The reaction mixture was quenched with 2M NaOH solution and DCM was added. The layers were partitioned and the aqs part was further extracted with DCM (2 times). The combined organic layers were dried over sodium sulfate and concentrated. Portioned between 2M NaOH and DCM and extracted the aqueous layer with DCM. Combined all organic layers and dried over Sodium sulphate. The crude was purified by column chromatography in 100-200 silica using Hexane/EtOAc (4: 1) as eluent to afford Intermediate 13 (290mg, 29.9%) as brown oil.

1120-88-3, 1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; THE BROAD INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION; INSTITUTO CARLOS SLIM DE LA SALUD; BURNS, Sean, M.; WAGNER, Bridget, K.; VETERE, Amedeo; (189 pag.)WO2018/175324; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-88-3,4-Methylpyridazine,as a common compound, the synthetic route is as follows.

1120-88-3, 3-(2,6-difluorophenyl)-2-fluorobenzoate (9.0 g, 0.026 mol) was dissolved in dry tetrahydrofuran (5 mL), the reaction flask was placed in a dry ice bath, cooling to -20C .Under nitrogen, was added dropwise LiHMDS (50 mL, 0.050 mol) was stirred for half an hour, the reaction flask moved to 0C ice bath, was slowly added dropwise 4-methyl pyridazine (2.5g, 0.027 mol), dropwise reactions were complete in 2 hours under ice-cooling, warmed to room temperature, saturated ammonium chloride solution (30 mL), (100 mL) and extracted with ethyl acetate, the organic phase was washed with water (30 mL) and saturated sodium chloride solution ( 30 mL), dried over anhydrous sodium sulfate, and the solvent removed by rotary evaporation, chromatographed to give the product (6.5 g, 61% yield) by silica gel column.

1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Tonghua Jida Pharmaceutical Co., Ltd.; Wu, yongqian; (22 pag.)CN103936728; (2016); B;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem