Category: 1114563-58-4

Application of 1114563-58-4, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a Patent，once mentioned of 1114563-58-4

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2079 – PubChem

 

Reference of 1114563-58-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a Patent，once mentioned of 1114563-58-4

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1114563-58-4. In my other articles, you can also check out more blogs about 1114563-58-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2081 – PubChem

 

1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, belongs to pyridazine compound, is a common compound. Recommanded Product: 6-Chloro-2,4-dimethylpyridazin-3(2H)-oneIn an article, once mentioned the new application about 1114563-58-4.

This invention relates to novel compounds of the Formula (I), (Ia1-10), (Ib1-10), (Ic1-10), (Id1-7), (Ie1-5) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11beta-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2078 – PubChem

 

Electric Literature of 1114563-58-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a Patent，once mentioned of 1114563-58-4

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1114563-58-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2079 – PubChem

 

Electric Literature of 1114563-58-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1114563-58-4, molcular formula is C6H7ClN2O, introducing its new discovery.

The present invention is directed to substituted pyridinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington’s disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1114563-58-4 is helpful to your research. Electric Literature of 1114563-58-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2080 – PubChem

 

Related Products of 1114563-58-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a article£¬once mentioned of 1114563-58-4

BROMODOMAIN INHIBITORS

The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1114563-58-4

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2077 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1114563-58-4, name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, introducing its new discovery. Formula: C6H7ClN2O

BET protein inhibitor, preparation method and application thereof (by machine translation)

The invention belongs to the technical field of biological medicines, and particularly relates to BET protein inhibitor, and a preparation method and application. Compared with the prior art, the BET protein inhibitor, based on the existing BET protein inhibitor, is further structurally improved, so that BET protein inhibitor with a new structure is obtained, the BET protein inhibitor has good BET protein inhibition activity and good pharmacokinetic properties, and the BET protein inhibitor is expected to be developed into a new generation high-efficiency and low-toxicity BET protein inhibitor. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1114563-58-4, and how the biochemistry of the body works.Formula: C6H7ClN2O

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2082 – PubChem

 

1114563-58-4, 6-Chloro-2,4-dimethylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1114563-58-4, Example 1 3-{(S)-1-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one 2 M aqueous Na2CO3 solution (0.31 mL) was added to a solution of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-[(S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl]-1,3-oxazinan-2-one (0.15 g) and 6-chloro-2,4-dimethyl-2H-pyridazin-3-one (75 mg) in N,N-dimethylformamide (1 mL). The resulting mixture was sparged with argon for 10 min, before [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) dichloromethane complex (15 mg) was added. The mixture was heated to 100 C. and stirred at this temperature overnight. After cooling to ambient temperature, water was added and the resulting mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4), and concentrated. The residue was purified by chromatography on silica gel (CH2Cl2/MeOH 98:2->80:20) to afford the title compound. Yield: 0.10 g (67% of theory); LC (method 1): tR=3.17 min; Mass spectrum (ES+): m/z=476 [M+H]+.

The synthetic route of 1114563-58-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/108578; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem