Category: 102-08-9

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 102-08-9, Name is N,N’-Diphenylthiourea. In a document, author is Imran, Mohd, introducing its new discovery. COA of Formula: C13H12N2S.

Design, Synthesis and Anti-Tubercular Activity of Isoniazid Derivatives

The aim of this study was to develop novel isoniazid derivatives, which can be utilized as antitubercular agents. The compounds were synthesized by reaction between the hydrazine unit of isoniazid with an appropriate lipophilic moiety. The compounds obtained were characterized on the basis of their melting points, R-f value, Fourier Transform Infra Red (FTIR) Spectra, H-1-Nuclear Magnetic Resonance (H-1-NMR) Spectra, C-13- Nuclear Magnetic Resonance (C-13-NMR) Spectra, Elemetal Analysis, and the Mass spectra. The novel compounds were assessed for their anti-tubercular activity by reported method against four strains of the Mycobacterium. The minimum inhibitory concentration of the active compounds was also determined. The anti-tubercular activity data revealed that most of the compounds have higher MIC values as compared to the standard drug isoniazid. Two compounds, namely 3b and 3c, exhibited very good anti-tubercular activity against all four strains of the Mycobacterium, which was comparable to the standard drug isoniazid. It has been concluded that the incorporation of a lipophilic chain at the position-2 of the pyridazine ring along with a halogen group, preferably a fluorine atom, at the p-position of the phenyl ring in this series of compounds increase the anti-tubercular activity of the compounds. However, this assumption cannot be generalized because in the present study the anti-tubercular activity was assessed against four strains of Mycobacterium. Accordingly, further studies are recommended to assess the anti-tubercular activity of these two compounds, 3b and 3c, against other strains of the Mycobacterium.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 102-08-9 help many people in the next few years. COA of Formula: C13H12N2S.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Application of 102-08-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a article, author is de Geus, Mark A. R., introduce new discover of the category.

Synthetic methodology towards allylictrans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of thelacrepressor

The inverse electron-demand Diels-Alder (IEDDA) pyridazine elimination is one of the key bioorthogonal bond-breaking reactions. In this reactiontrans-cyclooctene (TCO) serves as a tetrazine responsive caging moiety for amines, carboxylic acids and alcohols. One issue to date has been the lack of synthetic methods towards TCO ethers from functionalized (aliphatic) alcohols, thereby restricting bioorthogonal utilization. Two novel reagents were developed to enable controlled formation ofcis-cyclooctene (CCO) ethers, followed by optimized photochemical isomerization to obtain TCO ethers. The method was exemplified by the controlled bioorthogonal activation of thelacoperon system inE. coliusing a TCO-ether-modified carbohydrate inducer.

Application of 102-08-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 102-08-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of N,N’-Diphenylthiourea, 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S, belongs to pyridazines compound. In a document, author is Vajekar, Shailesh N., introduce the new discover.

Choline hydroxide promoted sustainable one-pot three-component synthesis of 1H-pyrazolo[1,2-a]pyridazine-2-carbonitriles under solvent-free conditions

A sustainable one-pot three-component synthesis of novel 1H-pyrazolo[1,2-a]pyridazine-2-carbonitrile derivatives employing a highly efficient, biodegradable, and recyclable choline hydroxide catalyst under solvent-free conditions is demonstrated. The salient features of this protocol are simple workup, mild reaction conditions, short reaction time (10 min), excellent yields (up to 97%), high atom economy, column chromatography-free protocol, and eco-friendliness. Interestingly, the choline hydroxide was recycled up to five cycles without any considerable loss of efficiency. The structures of the products were deduced by their H-1 NMR, C-13 NMR, and HRLC-MS spectra.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 102-08-9. Application In Synthesis of N,N’-Diphenylthiourea.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, Category: pyridazines, begins with the direct observation of nature¡ª in this case, of matter.102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a document, author is Javed, Athar, introduce the new discover.

Synthesis, antimicrobial activity, and docking study of some N-3, N-6-diphenylpyridazine-3,6-diamine derivatives as dihydrofolate reductase inhibitors

Objective: The present study focussed on the synthesis of pyridazine analogs to explore broad-spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are studied later. Materials and Methods: All the synthesized compounds were characterized by spectroscopic techniques, namely, UV, IR,(HNMR)-H-1, and mass spectrometry. Antimicrobial activity was screened by serial dilution method and absorbance was recorded using ELISA reader, subsequently minimum inhibitory concentrations were determined. Docking study was done into the active site of dihydrofolate reductase using Auto Dock 4.2. Results: The present investigation about synthesis, characterization, and biological studies of some new pyridazine analogs were carried out to obtain potent and pharmacologically active compounds. The free energy of binding was in the range of 5.12 to 8.97 kcal/mole. In silico study report was in good tune with laboratory experiments. Conclusions: Most of the compounds were moderate-to-good toward the antimicrobial activity. Compound AJ27 was found to be most active. Results of anti-microbial activity establishes the importance of N-3, N-6-diphenylpyridazine-3,6-diamine as the basic skeleton required for the antimicrobial activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Avdeev, Ya. G., once mentioned the application of 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S, molecular weight is 228.31, MDL number is MFCD00004921, category is pyridazines. Now introduce a scientific discovery about this category, Computed Properties of C13H12N2S.

Nitrogen-containing six-membered heterocyclic compounds as corrosion inhibitors for metals in solutions of mineral acids – A review

The current state of studies on metal protection from corrosion in mineral acid solutions by six-membered N-containing heterocyclic compounds is reviewed. Literature data on the protection of various metals in acid solutions by these compounds are summarized. The specific features of their protective action mechanism are discussed. The feasibility of metal protection by formulations containing these compounds, even in high-temperature corrosion, is noted. N-Containing six-membered heterocyclic compounds are prone to adsorption on metal surfaces from mineral acid solutions. Based on the free adsorption energy values of these corrosion inhibitors (CIs) on metal surfaces, it can be deemed with high probability that they are mostly bound to a metal by physical forces, but upon adsorption on its surface they slow down the cathodic and anodic reactions, and eventually inhibit its corrosion. Compounds containing S atoms or bulky substituents are most interesting. These compounds are adsorbed on metals more strongly and behave as more efficient CIs. It often happens that such CIs hinder metal corrosion in HCl solutions but do it much more weakly in H2SO4, HClO4, and H3PO4. A known method for improving the protective effect of N-containing six-membered heterocyclic CIs in these media involves combining them with anionic additives, e. g., halide or rhodanide anions. The heterocycles discussed behave as CIs in cold solutions but lose these properties at higher temperatures. Examples of the use of six-membered N-containing heterocycles as CIs of various steels and non-ferrous metals (Al, Cu, Sn, Zn and their alloys) are available in literature. The industrial application of individual six-membered N-containing heterocycles and their derivatives for metal protection in acid media is of little promise and is unjustified. It is more appropriate to use these compounds as components of inhibitor mixtures. Mixed CIs containing these compounds can hinder corrosion even in such corrosive media as high-temperature HCl solutions or hot H3PO4 solutions. The base for creating prospective mixed corrosion inhibitors for metals in acids should be searched for among six-membered heterocyclic compounds containing two or more nitrogen atoms or compounds obtained from natural raw materials. The bibliography includes 150 references.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S. In an article, author is Atalay, Vildan Enisoglu,once mentioned of 102-08-9, Quality Control of N,N’-Diphenylthiourea.

Antioxidative activity analyses of some pyridazine derivatives using computational methods

Pyridazine-derivative compounds have attracted considerable attention in different fields for many years due to their various biological activities such as antimicrobial and antitumoral. Simultaneously, antioxidative activity is one of the most important properties of them. With this perspective, antioxidative properties of eight different pyridazine derivatives have been investigated in accordance with three main mechanisms (HAT, SET, and SPLET). The investigation has been carried out with HF/6-31+G(d,p), B3LYP/6-31G(d,p), B3LYP/6-31+G(d,p), and MP2/6-31+G(d,p) level of theories in both gas and liquid phases. Furthermore, several molecular descriptors, bond and proton dissociation enthalpies, ionization potentials, proton affinities, and electron transfer enthalpies of investigated molecules have been calculated and antioxidative properties of the molecules have been sorted in accordance with the calculated values. Besides, effects of methods, basis sets, and solvent have been discussed. This computational study has determined the antioxidative capacity of 1A2D as the highest in each studied method and phases.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 102-08-9, Name is N,N’-Diphenylthiourea, formurla is C13H12N2S. In a document, author is Ibrahim, Hamada Mohamed, introducing its new discovery. Category: pyridazines.

The first Q-Tube based high-pressure synthesis of anti-cancer active thiazolo[4,5-c]pyridazines via the [4+2] cyclocondensation of 3-oxo-2-arylhydrazonopropanals with 4-thiazolidinones

A novel and efficient protocol for the synthesis of thiazolo[4,5-c]pyridazine derivatives was developed. The approach utilizes a high pressure Q-Tube reactor to promote cyclocondensation reactions between 3-oxo-2-arylhydrazonopropanals and 4-thiazolidinones. The process has a significantly high atom economy and a broad substrate scope, as well as being applicable to gram scale syntheses. The in vitro cytotoxic activities of the synthesized thiazolo[4,5-c]pyridazine derivatives were examined utilizing a MTT colorimetric assay with doxorubicin as a reference anti-cancer drug and three human cancer cell lines including HCT-116 (colon), MCF-7 (breast) and A549 (lung). The results show that thiazolopyridazines 7c, h, k and p have high cytotoxic activity against the MCF-7 cell line with respective IC50 values of 14.34, 10.39, 15.43 and 13.60 mu M. Moreover, the thiazolopyridazine derivative 7s also show promising cytotoxic activity against the HCT-116 cell line with IC50 = 6.90 mu M. Observations made in this effort serve as a basis for further investigations into the design and preparation of new anti-cancer drugs.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Related Products of 102-08-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a article, author is Chen, Zhicai, introduce new discover of the category.

All-acceptor polymers with noncovalent interactions for efficient ambipolar transistors

Exciting progress has been made recently regarding organic field-effect transistors (OFETs) owing to significant efforts devoted to the material design of semiconducting conjugated small molecules and polymers. However, the development of ambipolar or n-type OFETs lags behind that of p-type devices. Here, we propose a new strategy for the design of ambipolar polymers based on acceptors (A) of diazines (pyridazine or pyrazine) in a moderate A-weak A (mA-wA) architecture by integrating intrachain noncovalent interactions to rationally engineer the electronic structure, molecular planarity and backbone curvature of the conjugated copolymers. Thus designed mA-wA polymers with intrachain NMIDLINE HORIZONTAL ELLIPSISS interactions exhibit both high-lying HOMO and low-lying LUMO energy levels for ambipolar charge transport and good planarity with a linear backbone for high and balanced hole and electron mobilities up to 0.39 and 0.30 cm(2) V-1 s(-1), respectively. Furthermore, the flexible OFETs fabricated on polyethylene terephthalate substrates show high mobilities of 0.26 and 0.32 cm(2) V-1 s(-1) for holes and electrons, respectively. This design strategy with the newly discovered diazine acceptors to invoke both mA-wA and NCI effects in conjugated polymers for backbone engineering may be applicable to other systems, representing an advanced concept for the construction of high-performance ambipolar polymers.

Related Products of 102-08-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 102-08-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 102-08-9, Name is N,N’-Diphenylthiourea. In a document, author is Mao, Wuyu, introducing its new discovery. Product Details of 102-08-9.

A General Strategy to Design Highly Fluorogenic Far-Red and Near-Infrared Tetrazine Bioorthogonal Probes

Highly fluorogenic tetrazine bioorthogonal probes emitting at near-infrared wavelengths are in strong demand for biomedical imaging applications. Herein, we have developed a strategy for forming a palette of novel Huaxi-Fluor probes in situ, whose fluorescence increases hundreds of times upon forming the bioorthogonal reaction product, pyridazine. The resulting probes show large Stokes shifts and high quantum yields. Manipulating the conjugate length and pull-push strength in the fluorophore skeleton allows the emission wavelength to be fine-tuned from 556 to 728 nm. The highly photo-stable and biocompatible probes are suitable for visualizing organelles in live cells without a washing step and for imaging of tumors in live small animals to depths of 500 mu m by two-photon excitation.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 102-08-9 help many people in the next few years. Product Details of 102-08-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Rajagopal, Lakshmi, once mentioned the application of 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S, molecular weight is 228.31, MDL number is MFCD00004921, category is pyridazines. Now introduce a scientific discovery about this category, HPLC of Formula: C13H12N2S.

TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABA(A) receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia

GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABA(A) a2,3 subtype-selective GABA(A) partial agonist and alpha(1/5) antagonist, and the neurosteroid, pregnenolone sulfate, a GABA(A) antagonist, may improve CIAS in pilot clinical trials. The goal of this study was to investigate the effect of TPA-023 in mice after acute or subchronic (sc) treatment with the N-methyl-D-aspartate receptor (NMDAR) antagonist, phencyclidine (PCP), on novel object recognition (NOR), reversal learning (RL), and locomotor activity (LMA) in rodents. Acute TPA-023 significantly reversed scPCP-induced NOR and RL deficits. Co-administration of sub-effective dose (SED) TPA-023 with SEDs of the atypical antipsychotic drug, lurasidone, significantly potentiated the effect of TPA-023 in reversing the scPCP-induced NOR deficit. Further, scTPA-023 co-administration significantly prevented scPCP-induced NOR deficit for 5 weeks. Also, administration of TPA-023 for 7 days following scPCP reversed the NOR deficit for 1 week. However, TPA-023 did not blunt acute PCP-induced hyperactivity, suggesting lack of efficacy as a treatment for psychosis. Systemic TPA-023 significantly blocked lurasidone-induced increases in cortical acetylcholine, dopamine, and glutamate without affecting increases in norepinephrine and with minimal effect on basal release of these neurotransmitters. TPA-023 significantly inhibited PCP-induced cortical and striatal dopamine, serotonin, norepinephrine, and glutamate efflux. These results suggest that TPA-023 and other GABA(A) agonists may be of benefit to treat CIAS.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 102-08-9, HPLC of Formula: C13H12N2S.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem