Category: 10071-38-2

Application of 10071-38-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one,introducing its new discovery.

The invention relates to compounds of formula (I), wherein R1 and R3 are independently selected from carbon and nitrogen; R2 is oxo or thioxo; n is 0, 1 or 2; each R10 is independently selected from hydrogen and C1-3 alkyl; R4 and R5 are each selected from carbon and nitrogen, wherein at least one of R4 and R5 is nitrogen; R6 is hydrogen or oxo; R7 is an aliphatic, partially saturated or aromatic carbocyclic ring, said carbocyclic ring having 0, 1 or 2 hetero nitrogen; m is 0, 1 or 2; each R11 is independently selected from hydrogen, hydroxy, oxo, C1-5 alkyl, carboxy, hydroxy C1-5 alkyl, carboxy C1-5 alkyl, C1-5 alkoxyoxoC1-5alkyl, carbamoyl, C1-5alkylcarbamoyl, di (C1-5 alkyl)carbamoyl, carbamoylC1-4alkyl, C1-5alkylcarbamoylC1-4alkyl, di(C1-5alkyl)carbamoylC1-4alkyl, hydroxyC1-5alkylcarbamoyl, C1-5 alkoxyC1-5alkylcarbamoyl, hydroxyC1-alkylcarbamoylC1-4alkyl, C1-5alkoxyC1-5 alkylcarbamoylC1-4 alkyl, CONR80(CH2)xS(O)pR90, CONH(CH2)qNR100R100, -C1-5 alkyl-Y , -COOCHR170R180 and ¿CON R170R180; R8 is a bond, C1-4alkylene or C2-6alkenylene; R9 is an aromatic ring system having 0, 1 or 2 hetero atoms; wherein R9 is substituted by 0 or 1 halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10071-38-2, and how the biochemistry of the body works.Synthetic Route of 10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1103 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 10071-38-2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 10071-38-2

The invention relates to compounds of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R1, R2, R3 and R4 are independently selected from carbon and nitrogen, and where at least one of R1, R2, R3 and R4 is nitrogen; A1 is a single bond or a double bond; n is 0, 1, 2 or 3; each R5 is independently selected from hydrogen, halogen, C1-3 alkyl, oxo, oxy, oxido and thioxo; R6 is hydrogen or oxo; m is 0, 1, 2 or 3; A2 is a single bond or a double bond; each R7 is independently selected from hydrogen, hydroxy, oxo, C1-5alkyl, carboxy, cyano, tetrazolyl, N-C1-5alkyltetrazolyl, oxazolyl, C1-5oxazolyl, isoxazolyl, C1-5isoxazolyl, hydroxyC1-5alkyl, carboxy C1-5alkyl, C1-5alkoxyoxo C1-5alkyl, carbamoyl, C1-5alkylcarbamoyl, di(C1-5alkyl)carbamoyl, carbamoyl C1-4alkyl, C1-5alkylcarbamoyl C1-4alkyl, di(C1-5alkyl)carbamoyl C1-4alkyl, hydroxy C1-5alkylcarbamoyl, C1-5alkoxy C1-5alkylcarbamoyl, hydroxy C1-5alkylcarbamoyl C1-4alkyl, C1-5alkoxy C1-5alkylcarbamoyl C1-4alkyl, -CONR8(CH2)xS(O)pR9, -CONH(CH2)qNR10R11, -C1-5alkyl-Y1, -COOCHR17R18 and -CON R17 R18; and R30 is hydrogen, amino, methyl or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them

If you are interested in 10071-38-2, you can contact me at any time and look forward to more communication. Formula: C5H5ClN2O

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1104 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 10071-38-2, name is 6-Chloro-2-methylpyridazin-3(2H)-one, introducing its new discovery. name: 6-Chloro-2-methylpyridazin-3(2H)-one

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10071-38-2, and how the biochemistry of the body works.name: 6-Chloro-2-methylpyridazin-3(2H)-one

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1117 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C5H5ClN2O. Introducing a new discovery about 10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 10071-38-2, you can also check out more blogs about10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1112 – PubChem

Synthetic Route of 10071-38-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one, molecular formula is C5H5ClN2O. In a Patent，once mentioned of 10071-38-2

The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 10071-38-2. In my other articles, you can also check out more blogs about 10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1107 – PubChem

Reference of 10071-38-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 10071-38-2, molcular formula is C5H5ClN2O, introducing its new discovery.

This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10071-38-2 is helpful to your research. Reference of 10071-38-2

Referenceï¼?br>Pyridazine – Wikipedia,
Pyridazine | C4H4N1113 – PubChem

Application of 10071-38-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one, molecular formula is C5H5ClN2O. In a article，once mentioned of 10071-38-2

The synthesis of four new series of acyclic heteroaromatic receptors is described. They are built by two flexible polyether chains functionalised at their end with pyridazinone or methylpyridazine rings and connected by pyridine or benzene units. Their ability as carriers of lipophilic and hydrophilic phenethylamines and metallic cations has been evaluated. Transport rates show that, in general, these compounds are much more efficient carriers of lipophilic amines than of dopamine and Na+, K+ and Ca2+ ions. Their transport selectivities towards phenethylamine and homoveratrylamine are discussed on the basis of their structural features. Molecular modelling studies suggest that interaction of the aromatic moiety of the guest with the pyridazinone rings via double pi-stacking, or with the pyridine ring by single pi-stacking, should be responsible of their enhanced efficacy and selectivity in the transport of lipophilic phenethylamines.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1119 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C5H5ClN2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 10071-38-2

The present invention relates to compounds of general for­mula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particu­lar bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of dis­eases which can be influenced by this receptor, such as meta­bolic diseases, in particular diabetes type 2

If you are interested in 10071-38-2, you can contact me at any time and look forward to more communication. Computed Properties of C5H5ClN2O

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1111 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 6-Chloro-2-methylpyridazin-3(2H)-one. Introducing a new discovery about 10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one

Structure-activity relationship (SAR) investigations of a novel class of triazolopyridazinone p38alpha mitogen activated protein kinase (MAPK) inhibitors are disclosed. From these studies, increased in vitro potency was observed for 2,6-disubstituted phenyl moieties and N-ethyl triazolopyridazinone cores due to key contacts with Leu108, Ala157 and Val38. Further investigation led to the identification of three compounds, 3g, 3j and 3m that are highly potent inhibitors of LPS-induced MAPKAP kinase 2 (MK2) phosphorylation in 50% human whole blood (hWB), and possess desirable in vivo pharmacokinetic and kinase selectivity profiles.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of 6-Chloro-2-methylpyridazin-3(2H)-one, you can also check out more blogs about10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1121 – PubChem

Synthetic Route of 10071-38-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one, molecular formula is C5H5ClN2O. In a article，once mentioned of 10071-38-2

The synthesis, in vitro/in vivo antifungal evaluation and a structure-activity relationship (SAR) study of 3(2H)-pyridazinones was carried out. The results reported here may be helpful in the structural identification and understanding of the minimum structural requirements for these molecules acting as antifungal agents. In addition, the most active structure in this series was tested for its capacity of inhibiting Saccharomyces cerevisiae beta1,3-glucan synthase and chitin synthase, enzymes that catalyze the synthesis of the major polymers of the fungal cell wall.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10071-38-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1122 – PubChem