89466-38-6, 6-Chloro-3-methoxy-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 6- chloro-3-methoxy-4-methylpyridazine (3.31 g, 20.9 mmol) in 4:1 dioxane: water (100 mL) was treated with 12.0 M HC1(aq) (1.91 mL, 23.0 mmol) and stirred for 60 h at 60 C. The reaction mixture was concentrated under vacuum, and the resulting crude residue was purified by silica chromatography (1-30% DCMIMeOH with 2% NH4OH as the gradient eluent) to afford the title compound (2.99 g, 99% yield). ?HNMR(400 IVIFIz, DMSO-d6) 13.03 (s, 1H), 7.44 (s, 1H), 2.05 (s, 3H).
The synthetic route of 89466-38-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; COOK, Adam; GUNAWARDANA, Indrani W.; HUNT, Kevin W.; METCALF, Andrew T.; MORENO, David; REN, Li; TANG, Tony P.; (263 pag.)WO2017/70708; (2017); A1;,
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