We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 13327-27-0, and how the biochemistry of the body works.Related Products of 13327-27-0
Related Products of 13327-27-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article£¬once mentioned of 13327-27-0
Pyridazinones. 2. Synthesis and Antisecretory and Antiulcer Activities of Thiourea and 2-Cyanoguanidine Derivatives
In an effort to develop new types of antiulcer agents, we synthesized a series of novel 2-– and 2--3-(2H)-pyridazinone derivatives.All target compounds were evaluated for gastric antisecretory activity in the pylorus-lygated rat by the method of Shay, and selected compounds were evaluated in the stress-induced ulcer test in rats.Structure-activity relationships were esthablished.Two series of the compounds had significant activity in antisecretory and/or antiulcer tests.The molecular features essential for the activities are a thiourea group or a 2-cyanoguanidine group, a phenyl group in the C-6 position of the 3(2H)-pyridazinone ring, a four-carbon chain length between the 3(2H)-pyridazinone ring and the functional group, and a methyl group at the N-3 position of the functional group.Among them, the three thiourea derivatives (24, 26, and 38) and the six 2-cyanoguanidine derivatives (61,62,65,75,85, and 86) had the most potent antisecretory and/or antiulcer activities.These compounds are not histamine H2-receptor antagonists.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 13327-27-0, and how the biochemistry of the body works.Related Products of 13327-27-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N329 – PubChem