With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144294-43-9,3-Amino-5-methylpyridazine,as a common compound, the synthetic route is as follows.
0158-2 A mixture of 6-chloro-N-(5-(2-morpholinoethoxyl)pyridin-3-yl)-1,5-naphthyridine-3-amine (10 mg), 5-methylpyridazine-3-amine (4 mg), tris(dibenzylideneacetone)dipalladium(0) (5 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (10 mg), and cesium carbonate (20 mg) in 1,4-dioxane (1 mL) was stirred at 140 C. for 30 minutes using a microwave reaction apparatus. The reaction mixture was cooled to room temperature, the insolubles were filtered off using celite, and the obtained solution was purified by silica gel column chromatography (methanol-ethyl acetate, NH silica), thereby obtaining N2-(5-methylpyridazin-3-yl)-N7-(5-(2-morpholinoethoxyl)pyridin-3-yl)-1,5-naphthyridine-2,7-diamine (1.9 mg). 1H-NMR(CDCl3/CD3OD=4/1) delta: 8.67 (1H, brs), 8.63 (1H, brs), 8.50 (1H, brs), 8.14 (1H, brs), 8.11 (1H, d, J=9.0 Hz), 7.91 (1H, brs), 7.78 (1H, brs), 7.24 (1H, d, J=9.0 Hz), 7.21 (1H, brs), 4.20 (2H, t, J=5.4 Hz), 3.79-3.71 (4H, m), 2.85 (2H, t, J=5.4 Hz), 2.66-2.56 (4H, m), 2.43 (3H, s). MS m/z (M+H): 459.
The synthetic route of 144294-43-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
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