With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50681-25-9,4-Pyridazinecarboxylic Acid,as a common compound, the synthetic route is as follows.
Intermediate 29 Step A: A solution of pyridazine-4-carboxylic acid (92.5 mg, 0.754) and 2-(7-aza- 1H- benzotriazole-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (283 mg, 0.745 mmol) in 1 : 1 CH2C12/DMF (10 mL) was treated with NEt3 (108 mg, 1.06 mmol) and stirred for 10 min. A solution of 1-28 (224 mg, 0.56 mmol) in 1: 1 CH2C12/DMF (10 mL) was then added and the mixture was stirred for lh (reaction completion monitored by LC/MS). The solvent was evaporated under reduced pressure and the residue was dissolved in CH2CI2 (4 mL), treated with Na2CC>3 (178 mg, 1.68 mmol) and stirred for 3 minutes. The mixture was then purified by column chromatography (MeOH in CH2CI2, 0% to 10%) to afford (R)-tert-buty 3-(7-chloro-6-methoxy-2-(pyridazine-4- carboxamido)-lH-benzo[d]imidazol-l-yl)azepane-l-carboxylate (I-29a). MS calculated for C24H30CIN6O4 (M+H+) 501.19, found 501.2.
The synthetic route of 50681-25-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IRM LLC; LELAIS, Gerald; EPPLE, Robert; MARSILJE, III, Thomas H.; MICHELLYS, Pierre-Yves; MCNEILL, Matthew H.; LONG, Yun; LU, Wenshuo; CHEN, Bei; BURSULAYA, Badry; JIANG, Songchun; WO2013/184757; (2013); A1;,
Pyridazine – Wikipedia
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