With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
General procedure: Appropriate 3(2H)-pyridazinone derivative (0.01 mol), ethyl bromoacetate (0.015 mol) and anhydrous potassium carbonate (0.02 mol) in 20 mL of anhydrous DMF were stirred at room temperature for 2 h, respectively. At the end of this period, the reaction mixture was poured into ice water and the resulting precipitate was filtered to give compounds 4 (mp 97 C; lit [20]: 92 C), 5 (mp 100-102 C; lit [21]:101C), 6 (mp 159 C; lit [22]:155 C), respectively., 2166-31-6
As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.
Reference£º
Article; Sukuroglu, Murat; Yamali, Cem; Tiryaki, Didem; Onurdag, Fatma Kaynak; Akkol, Esra; Dogruer, Deniz Songuel; Letters in drug design and discovery; vol. 10; 6; (2013); p. 507 – 514;,
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