34584-69-5, 3,6-Dichloro-4,5-dimethylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine (10 g, 43.3 mmol) is combined with 3,6-dichloro-4,5-dimethyl-pyridazine (14.4 g, 84.3 mmol), triethylamine (8.25 mL), and NMP (40 mL). The reaction mixture is heated to a temperature of 180¡ã C. for 25 min, and then concentrated in vacuo. The residue is purified by flash chromatography on silica gel (0-8percent MeOH/CH2Cl2) to afford the title compound (13.2 g, 82percent). 1H NMR (400 MHz, DMSO-d6) delta=8.48-8.41 (m, 1H) 7.84 (dd, J=9.1 Hz, 2.4 Hz, 1H) 7.03 (d, J=9.1 Hz, 1H) 3.88-3.76 (m, 4H) 3.28-3.20 (m, 4H) 2.31 (s, 6H).
The synthetic route of 34584-69-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem