With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123169-25-4,6-Bromo-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
1123169-25-4, In the reaction vessel RuPhos Indoline Precatalyst (0.058 g, 0.079 mmol) and sodium tert-butoxide (0.305 g, 3.17 mmol) were combined, followed by 6-bromo-2-methylpyridazin-3 (2H) -one (0.300 g, 1.587 mmol) and tert-butyl 1-oxa-4, 9-diazaspiro [5.5] undecane-9-carboxylate (0.488 g, 1.905 mmol) . This mixture was then evacuated and backfilled with N2 (3 times) . Then dry, degassed tetrahydrofuran (7.9 mL) was added to this flask. This mixture was heated at 80 overnight. The mixture was cooled and solvent was removed on a rotavapor. The residue was dissolved in 40 mL of EtOAc and 20 mL of water. After separation, aqueous layer was extracted with EtOAc (20mL x 2) . The organic layers were combined and washed with 20 mL brine. Then it was dried over Na2SO4. Removing solvent gave the crude product, wich was purifed by column chromatography (40g slica gel column, eluted with 100 EtOAc) to afford the title compound. LC-MS (IE, m/z) : 365 (M+1) +.
As the paragraph descriping shows that 1123169-25-4 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; SHI, Zhi-Cai; WALSH, Shawn P.; WU, Zhicai; YU, Yang; FERGUSON II, Ronald; GUO, Zhiqiang; FRIE, Jessica; SUZUKI, Takao; BLIZZARD, Timothy A.; FU, Qinghong; VANGELDER, Kelsey F.; (118 pag.)WO2016/65582; (2016); A1;,
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