932-22-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.
Add 4,5-dichloro-3(2H)-pyridazinone 9.00g (0.055 mol) to a 250 mL three-necked flask. 11.50 g (0.063 mol) of alpha-chloroacetophenone, 11.40g (0.083mol) of potassium carbonate with 100mL of DMF, the reaction was carried out at 60 C for 8 hours. The reaction solution was cooled to room temperature and poured into a beaker containing 150 mL of ice water. A large amount of precipitate appeared on the mixture, suction filtration, and the filter cake was washed three times with water and dried. Recrystallization from ethyl acetate / ethanol gave 12.38 g. Yield 72.8%
The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai University of Engineering Science; Li Hongsen; Sun Yanwen; Wu Haolei; Wei Changheng; Gao Mei; Shen Zeyi; (16 pag.)CN108503590; (2018); A;,
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