14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 3,4,5-trichloropyridazine (0.50 g, 2.73 mmol), 1-(4- fluorophenyl)piperazine (0.511 g, 2.83 mmol), and potassium carbonate (0.79 1 g, 5.72 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooledand 35% hydrazine (4.94 ml, 54.5 mmol) was added. The mixture was heated to reflux for 16 h overnight. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(4-fluorophenyl)piperazin- 1 -yl)-3 – hydrazinylpyridazine (0.880 g, 100%), which was used without purification. LCMS:
The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
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