With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53180-92-0,5-Chloropyridazin-4-amine,as a common compound, the synthetic route is as follows.,53180-92-0
Preparation 9.2: 5-(2-methylpyridin-3-yl)pyridazin-4-amine 7v [00288] A mixture of 5-chloropyridazin-4-amine (50 mg, 0.386 mmol), (2-methyl-3- pyridyl)boronic acid (63.43 mg, 0.463 mmol), palladium triphenylphosphane (22.3 mg, 0.0193 mmol) and a2C03 (386 mu^ of 2M, 0.772 mmol) in dioxane (2 mL) was heated at 140C for lh. The mixture was then cooled to room temperature and partitioned between DCM and water. The organic layer was filtered through a SCX column, eluting with a 2M solution of H3 in MeOH. The eluate was concentrated in vacuo to give the title compound 7v (72 mg, 100% Yield).
The synthetic route of 53180-92-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
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