5096-73-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Example 4 2-[6-((1R,2R)-1-Benzyl-2-carboxy-2-hydroxy-ethylcarbamoyl)-pyridazin-3-yl]-benzoic Acid (R1=-OH; R41=H) 6-Chloropyridazine-3-carboxylic acid (78.9 mg, 497 mumol, 1.0 eq.), DIPEA (273 muL, 3.2 eq.), HATU (189 mg, 497 mumol, 1.0 eq.), and (2R,3R)-3-amino-2-hydroxy-4-phenyl-butyric acid ethyl ester (129 mg, 497 mumol, 1.0 eq.) were combined in DCM (2 mL) and stirred for 1 hour. The crude reaction was chromatographed using a gradient (0-80% EtOAc/Hex) to obtain (2R,3R)-3-[(6-chloro-pyridazine-3-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid ethyl ester.
As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.
Reference£º
Patent; THERAVANCE, INC.; US2012/309724; (2012); A1;,
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