90766-97-5,90766-97-5, 5-Bromo-6-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-bromo-6-phenylpyridazin-3(2H)-one (1.522 g, 6.06 mmol) in DMF (90 mL) was added tert-buty 2-(((ls,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate (2.50 g, 6.06 mmol), potassium 2-methylpropan-2-olate (1.360 g, 12.12 mmol) and 18-crown-6 (0.320 g, 1.212 mmol). The reaction was stirred at 40 0C for 16 h, quenched with water (40 mL), extracted with EtOAc (4 x 50 mL), and washed with brine. The combined organic phases were dried over MgSO4, filtered, and concentrated to give a brown oil. The brown oil was purified by silica gel column chromatography to give the title compound as a yellow oil (1.346 g). LCMS mlz = 491.3 [M+Eta]+; 1H NMR (400 M Hz, CDCl3) delta ppm, 1.37-1.64 (m, 17H), 1.80-1.90 (m, IH), 2.23 (bs, IH), 3.42 (d, J= 7.07 Hz, 2H), 3.94 (s, 2H), 4.17 (d, J = 7.71 Hz, 2H), 7.44-7.49 (m, 4H), 7.50-7.55 (m, 2H).
As the paragraph descriping shows that 90766-97-5 is playing an increasingly important role.
Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; HAYASHI, Rena; IBARRA, Jason B.; ULLMAN, Brett; ZOU, Ning; WO2010/77275; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem