17321-29-8, 3-Bromo-6-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of diisopropylamine(0.74 mL, 5.19 mmol) in THF (15 mL) was added butyl lithium (3.2 mL, 5.12 mmol) at 0 C. The resulting mixture was stirred was stirred for 15 min and the resulting LDA solution was cooled to -78 C . A solution of 3-bromo-6-methoxypyridazine (800mg, 4.23 mmol) in THF (5 mL) was added dropwise to the LDA solution. After 5 min DMF (0.4 mL, 5.17 mmol) was added and the mixture was stirred for lh at -15 C. The reaction mixture was quenched with sat aq. ammonium chloride solution (50 mL) and extracted with EtOAc. The combined organic layers were dried over sodium sulfate, filtered, concentrated under reduced pressure. Purified by flash column chromatography to give the desired product 6- bromo-3-methoxypyridazine-4-carbaldehyde 760 mg).
17321-29-8, As the paragraph descriping shows that 17321-29-8 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ARRINGTON, Kenneth, L.; BURGEY, Christopher; GILFILLAN, Robert; HAN, Yongxin; PATEL, Mehul; LI, Chun Sing; LI, Yaozong; LUO, Yunfu; LEI, Zhiyu; XU, Jiayi; WO2014/58747; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem