With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.933-76-6,4,5-Dichloro-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
Step A: Preparation of 5 -chloro-4-(2-methoxyethoxy)-2-methyl-3 (2H)-pyridazinone 4,5-Dichloro-2-methyl-3(2H)-pyridizinone (2.0 g, 11 mmol), 2-methoxyethanol (1.06 mL, 13.4 mmol) and sodium hydride (0.672 g, 16.8 mmol) were combined in 30 mL of dioxane and stirred at ambient temperature overnight. The reaction mixture was then poured over 100 mL of an ice/water mixture and extracted into ethyl acetate. The organic layer was washed with brine, dried (Mg504) and absorbed onto silica gel. Chromatography throughsilica gel eluting with a gradient of 0 to 100% ethyl acetate in hexanes provided 1.76 g of the title product as a white solid.1H NMR (500 MHz) oe 7.69 (s, 1H), 4.7 1-4.77 (m, 2H), 3.75 (s, 3H), 3.69-3.72 (m, 2H),3.39 (s, 3H)., 933-76-6
933-76-6 4,5-Dichloro-2-methylpyridazin-3(2H)-one 120462, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; STEVENSON, Thomas, Martin; WO2014/31971; (2014); A1;,
Pyridazine – Wikipedia
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