88491-61-6,88491-61-6, 3-Bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Zinc powder (0.12 g, 1.8 mmol) was added to a dry flask purged with nitrogen. Dry DMF (1.0 ml) was added followed by iodine (43 mg, 0.2 mmol). The solution changed from colourless to yellow and then back to colourless. Methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3- lodopropanoate (0.20 g, 0.60 mmol) was added, followed by iodine (43 mg, 0.2 mmol). The solution was stirred at ambient temperature, with an exotherm observed. To this solution was added Pd2(dba)3(28 mg, 0.04 mmol), SPhos (25 mg, 0.12 mmol) and 3-bromopyridazine (0.25 g, 1.6 mmol). The RM was stirred at rt under nitrogen for 18 h. The RM was filtered twice and purified by FCC (silica, EtOAc / hexane) to give the desired product.Y = 43 % MS ES+: 282
As the paragraph descriping shows that 88491-61-6 is playing an increasingly important role.
Reference£º
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOUTARD, Nicolas; FABRITIUS, Charles-Henry; GALEZOWSKI, Michal; KOWALCZYK, Piotr; LEVENETS, Oleksandr; WOYCIECHOWSKI, Jakub; (161 pag.)WO2018/167468; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem