120276-59-7, 3-Chloro-6-(chloromethyl)pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (6-(4-hydroxy-2-oxopyridin-l(2H)-yl)-7,8-dihydronaphthalen-2-yl)methyl acetate (2 g, 6.42 mmol), 3-chloro-6-(chloromethyl)pyridazine (1.047 g, 6.42 mmol) and potassium carbonate (0.888 g, 6.42 mmol) in Nu,Nu-dimethylformamide (DMF) (40 mL) was heated to 80 C for 6 hr, then the mixture was filtered and concentrated to give the residue which was purified by a flash column to give (6-(4-((6-chloropyridazin-3-yl) methoxy)-2- oxopyridin- l(2H)-yl)-7,8-dihydronaphthalen-2-yl)methyl acetate (2.4 g, 4.93 mmol, 77% yield): 1H NMR (400 MHz, CDC13) delta ppm 7.65 (d, J = 8.8 Hz, 1H), 7.58 (d, J = 8.8 Hz, 1H), 7.25-7.23 (m, 1H), 7.17-7.16 (m, 2H), 7.06 (dd, J = 4.8, 3.2 Hz, 1H), 6.45 (s, 1H), 6.04-5.98 (m, 2H), 5.37 (s, 2H), 5.06 (s, 2H),3.04 (t, J = 8.4 Hz, 2H), 2.73 (t, J = 8.4 Hz, 2H), 2.1 1 (s, 3H); ES-LCMS m/z 438 ( +H)+.
120276-59-7, 120276-59-7 3-Chloro-6-(chloromethyl)pyridazine 22498639, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min; WO2013/166621; (2013); A1;,
Pyridazine – Wikipedia
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