Pyridazines. LXV. Reactions of some 1-phenacylazolopyridazinium halides with 2,3-diphenylcyclopropenone, -thione, or hydrazine was written by Koren, B.;Stanovnik, B.;Tisler, M.. And the article was included in Journal of Heterocyclic Chemistry in 1974.Quality Control of Imidazo[1,2-b]pyridazine This article mentions the following:
1-Phenacylazolo-pyridazinium bromides I (R = H, Cl, X = CH; R = H, X = N) reacted with 2,3-diphenylcyclopropenone or -thione in the presence of Et3N to give the pyrones II (X1 = O, S) and the azolopyridazines III. I (R = H, Cl, X = CH) reacted with N2H4 to give either 3,6-diphenylpyridazine and III (R = H, NHNH2, X = CH) or by ring opening of the azine part to give 1-methyl-2-(5-pyrazolyl)imidazole. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Quality Control of Imidazo[1,2-b]pyridazine).
Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Quality Control of Imidazo[1,2-b]pyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem