A bifunctional small molecular photocatalyst with a redox center and a Lewis acid site for one-pot tandem oxidation-acetalization was written by Rao, Cai-Hui;Ma, Shuai;Cui, Jing-Wang;Jia, Meng-Ze;Yao, Xin-Rong;Zhang, Jie. And the article was included in Green Chemistry in 2022.Synthetic Route of C4H2Cl2N2 This article mentions the following:
By combining the double identity of a redox center and a Lewis acid site of the pyridinium derivative, the first bifunctional small mol. photocatalyst was developed for the one-pot tandem oxidation-acetalization reaction. A mechanism study revealed that pyridinium-mediated electron transfer and the photoactivation of mol. oxygen greatly facilitate the transformation of benzyl alcs. into the corresponding aldehydes, while the Lewis acid site of this bifunctional photocatalyst promoted a highly efficient acetalization reaction without any significant loss in activity after multiple reaction cycles, thus achieving the direct conversion of various alcs. into either cyclic or acyclic acetals in good yields under mild conditions without any additives. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Synthetic Route of C4H2Cl2N2).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Synthetic Route of C4H2Cl2N2
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem