Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides was written by Tomori, Takahito;Miyatake, Yuya;Sato, Yuta;Kanamori, Takashi;Masaki, Yoshiaki;Ohkubo, Akihiro;Sekine, Mitsuo;Seio, Kohji. And the article was included in Organic Letters in 2015.Application In Synthesis of 3-Aminopyridazine This article mentions the following:
Synthesis of peptide nucleic acids (PNAs) is reported with new pyridazine-type nucleobases: 3-aminopyridazine (aPz) and 1-aminophthalazine (aPh) as cytosine analogs, and pyridazin-3-one (PzO) and phthalazin-1-one (PhO) as thymine analogs. The PNAs having an aPz or a PzO formed duplexes with each complementary oligodeoxynucleotide forming a base pair with G or A, resp., as evaluated by using UV melting analyses and CD (CD) spectra. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Application In Synthesis of 3-Aminopyridazine).
3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application In Synthesis of 3-Aminopyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem