An expeditious one-pot multicomponent synthesis of sterically hindered bis-1,2,4-triazolopyridazines under solvent-free conditions was written by Aggarwal, Ranjana;Mamta;Sumranb, Garima. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2019.Reference of 141-30-0 This article mentions the following:
A simple and ecol. facile synthesis of sterically hindered 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b:3′,4′-f]pyridazines was accomplished via a three-component reaction sequence between 3,6-dihydrazinopyridazine, an aromatic or heteroaromatic aldehydes and iodobenzene diacetate (IBD) on grinding at room temperature The 3,6-bis-arylidenehydrazinopyridazine intermediates, generated in-situ, undergo oxidative cyclization to afford the title compounds The present protocol was excellent yields, short reaction times, broad substrate scope, solvent-free greener synthesis and was an easy purification of product. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Reference of 141-30-0).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Reference of 141-30-0
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem