Synthesis of imidazo[1,2-b]pyridazine was written by Lu, Hongguo;Xu, Yungen;Ren, Dong;Zhou, Bin. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2006.COA of Formula: C6H5N3 This article mentions the following:
A method for the synthesis of the title compound is reported here. This compound is an intermediate for cefozopran [i.e., 1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium inner salt]. Imidazo[1,2-b]pyridazine was synthesized from 3,6-dichloropyridazine by ammonolysis to give 3-amino-6-chloropyridazine, which was subjected to condensation and cyclization followed by catalytic hydrogenolysis (overall yield 85.4%). In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2COA of Formula: C6H5N3).
Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H5N3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem