Synthesis of New 6-[4-(2-Fluorophenylpiperazin-1-yl)]-3(2H)-Pyridazinone-2-Acetyl-2- (Substituted benzal)Hydrazone Derivatives and Evaluation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines was written by Ozdemir, Zeynep;Basak-Turkmen, Nese;Ayhan, Idris;Ciftci, Osman;Uysal, Mehtap. And the article was included in Pharmaceutical Chemistry Journal in 2019.Application of 141-30-0 This article mentions the following:
In this study, seven new 3(2H)-pyridazinone derivatives I (R = H, 2-Cl, 4-NMe2, 4-Me, 4-Cl, 4-Br, 2-MeO) expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Compounds I were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] proliferation assay. Human fibroblast cells were used as a safety control in these tests. Compound I (R = 2-Cl) was the most active agent with respect to HEP3B and HTC116 cell lines. In the experiment, the researchers used many compounds, for example, 3,6-Dichloropyridazine (cas: 141-30-0Application of 141-30-0).
3,6-Dichloropyridazine (cas: 141-30-0) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Application of 141-30-0
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem