Study on the synthetic condition of aryloxypyridazinoxy lactates – effect of halides in 3,6-dihalide pyridazines on nucleophilic substitution reaction was written by Hu, Fang-Zhong;Wang, Xiang;Ren, Kang-Tai;Yang, Hua-Zheng. And the article was included in Youji Huaxue in 2002.Related Products of 33097-39-1 This article mentions the following:
The synthetic condition of aryloxypyridazinoxy lactates was studied. Aryloxypyridazinoxy lactates can be obtained by two methods. The effect of halides in 3,6-dihalide pyridazines on nucleophilic substitution reaction was studied, too. Calculation of mol. mechanics and quantum chem. indicated that 3,6-difluoropyridazine had an advantage over other 3,6-dihalide pyridazines when it was treated with nucleophilic reagents and confirmed by the exptl. results. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Related Products of 33097-39-1).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Related Products of 33097-39-1
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem