Synthesis and herbicidal activity of 3-aryloxy-6-chloro(or fluoro)pyridazines was written by Wang, Zhanping;Hu, Fangzhong;Zou, Xiaomao;Yang, Xiufeng;Yang, Huazheng. And the article was included in Nongyaoxue Xuebao in 2004.HPLC of Formula: 33097-39-1 This article mentions the following:
3-Aryloxy-6-chloro(or fluoro)pyridazines I (X = Cl, F; R = Me, NO2, Cl, CF3, NH2, Br, OMe, COOEt, etc.) were prepared from the condensation of various substituted phenols with starting material 3, 6-dichloropyridazine and its fluorinated derivative, 3, 6-difluoropyridazine in high yields. All compounds were characterized by 1H NMR and elemental analyses, and some of the compounds were confirmed by IR. Preliminary bioassay indicates that some of the title compounds showed herbicidal activity to some extents against Brassica napus and Echinochloa crus-galli, for example, at 100 μg/mL, the inhibition of compounds I (X = Cl, R = 3-Me, 3-NO2 and X = F, R = 3-Me) against E. crus-gall are 95.7%, 96.1% and 91.2% , resp. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1HPLC of Formula: 33097-39-1).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.HPLC of Formula: 33097-39-1
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem