Synthesis and herbicidal evaluation of 3-N-substituted amino-6-benzyloxypyridazine derivatives was written by Zhang, Min;Hu, Fang-Zhong;Zhao, Ting;Yang, Liu-Qing;Yang, Hua-Zheng. And the article was included in Journal of Heterocyclic Chemistry in 2014.Reference of 33097-39-1 This article mentions the following:
A variety of 3-amino-6-benzyloxypyridazine derivatives I (R1 = 2-OMe, 3,5-Me2, 4-NO2, etc.; R2 = NMe2, piperidin-1-yl, morpholin-4-yl) were designed and synthesized in satisfactory yields. The compound I (R1 = 4-NO2; R2 = piperidin-1-yl) was further determined by X-ray diffraction crystallog. The synthesized compounds herbicidal activities were evaluated against barnyard grass and rape. Most of the compounds I displayed moderate herbicidal activities against the dicotyledonous plant Brassica campestris L. The most active compounds in the laboratory were also evaluated in the greenhouse. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Reference of 33097-39-1).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Reference of 33097-39-1
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem