Pyridazines. IX. Proton(nuclear)magnetic resonance studies of pyridazine, pyrazine, and substituted pyridazines was written by Tori, Kazuo;Ogata, Masaru. And the article was included in Chemical & Pharmaceutical Bulletin in 1964.Application In Synthesis of 3-Methoxypyridazine This article mentions the following:
CA 59, 5962b. Pyridazine (I) gives an A2X2 spectrum, τ3 = τ6 = 0.76, τ4 = τ5 = 2.46, J34 = 4.9 cycles/sec., J35 = 2.0, J36 = 3.5, J46 = 2.0, J45 = 8.4, and J56 = 4.9. 4Me-I and 3Me-I give ABX spectra. Pyrazine (II) gives a singlet τ = 1.37, J25 = 1.8, J26 = 0.5, J35 = 0.5, J36 = 1.8, and J56 = 1.8 (calculated from C13 satellites). The values of τ and J and the chem. shift of the protons in I due to substitution are comparable with other heteroaromatic systems. π electron ds. calculated from the ring proton chem. shift compared with C6H6 and compared with those calculated by the Hueckel M.O. method show large discrepancies in the case of I and II compared with pyrimidine (III). This effect is owed to the anisotropy of the N lone pair, which is mutually cancelled in III. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Application In Synthesis of 3-Methoxypyridazine).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application In Synthesis of 3-Methoxypyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem